Observational studyMedicine2016
Serial serum alkaline phosphatase as an early biomarker for osteopenia of prematurity.
Observational study in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Continuous versus intermittent bolus infusion of calcium in preterm infants receiving total parenteral nutrition: a randomized blind clinical trial.BMC pediatrics · 2024Trial
- Fractures Associated with Metabolic Bone Disease in Extremely Preterm and Extremely Low Birth Weight Infants Before and After a Bone Health Program.Children (Basel, Switzerland) · 2025Article
- Calcium and Phosphorus Intake in Very Low Birth Weight Preterm Infants: Implications for Osteopenia Prevention and Growth.Pediatric gastroenterology, hepatology & nutrition · 2025Article
- A case report of osteopenia of prematurity.Radiology case reports · 2024Article
- Analysis of clinical risk factors for metabolic bone disease of prematurity.Frontiers in pediatrics · 2024Article
- Relationship of caffeine regimen with osteopenia of prematurity in preterm neonates: a cohort retrospective study.BMC pediatrics · 2022Article
- Alkaline Phosphatase Electrochemical Micro-Sensor Based on 3D Graphene Networks for the Monitoring of Osteoblast Activity.Biosensors · 2022Article
- Factors Affecting Metabolic Bone Disease of Prematurity: Is Hypothyroxinemia Included?Sisli Etfal Hastanesi tip bulteni · 2022Review
- Enzymatically Forming Intranuclear Peptide Assemblies for Selectively Killing Human Induced Pluripotent Stem Cells.Journal of the American Chemical Society · 2021Article
- Expert consensus on clinical management of metabolic bone disease of prematurity (2021).Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
- Update on Calcium and Phosphorus Requirements of Preterm Infants and Recommendations for Enteral Mineral Intake.Nutrients · 2021Review
- Associated neonatal and maternal factors of osteopenia of prematurity in low resource setting: A cross-sectional study.Annals of medicine and surgery (2012) · 2021Article
- Screening of Serum Alkaline Phosphatase and Phosphate Helps Early Detection of Metabolic Bone Disease in Extremely Low Birth Weight Infants.Frontiers in pediatrics · 2021Article
- Article
- Metabolic Bone Disease of Prematurity: Risk Factors and Associated Short-Term Outcomes.Nutrients · 2020Observational
- Electrochemical Detection and Capillary Electrophoresis: Comparative Studies for Alkaline Phosphatase (ALP) Release from Living Cells.Biosensors · 2020Article
- Effect on metabolic bone disease markers in the neonatal intensive care unit with implementation of a practice guideline.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Association of Protein and Vitamin D Intake With Biochemical Markers in Premature Osteopenic Infants: A Case-Control Study.Frontiers in pediatrics · 2020Article
- Overview of Optical and Electrochemical Alkaline Phosphatase (ALP) Biosensors: Recent Approaches in Cells Culture Techniques.Biosensors · 2019Review
- Nutritional Support of Very Low Birth Weight Infants in a Tertiary Center in a Developing Country.Journal of clinical medicine research · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic bone disease of prematurity is a condition characterized by reduction in bone mineral content (osteopenia). It is a problem faced by very low birth weight (VLBW) infants because of lack of fetal mineralization during the last trimester. Our aim was to assess serum alkaline phosphatase (ALP) level as an early biomarker for osteopenia in premature infants and to estimate an optimal cutoff value of serum ALP at which osteopenia is detected radiologically in premature newborns.This prospective study was conducted on a cohort of 120 newborn infants of both sex of ≤34 weeks' gestational age and <1500 g birth weight. Two blood samples, from each infant on at least 2 consecutive weeks, were reported for calcium, phosphorus, and ALP. Evidence of osteopenia was evaluated radiologically by performing wrist/knee x-ray.Sixteen infants (13.3%) had evidence of osteopenia in x-ray, whereas 104 infants (86.7%) were nonosteopenic and all the osteopenic infants were <1000-g birth weight. Birth weight and gestational age were significantly inversely related to serum ALP levels. Both samples showed statistically significantly higher mean ALP level in osteopenic than nonosteopenics (P < 0.001, and P < 0.001 respectively). There was no constant value of serum ALP related to radiologic evidence of osteopenia. However, the optimal cutoff value of serum ALP at which osteopenia is detected is 500 IU/L with 100% sensitivity and 80.77% specificity.High levels of ALP can be considered a reliable biomarker to predict the status of bone mineralization and the need for radiological evaluation in premature infants particularly those <1000-g birth weight and <32 weeks' gestation.
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