Observational studyMedicine2016
Bidirectional association between obstructive sleep apnea and depression: A population-based longitudinal study.
Observational study in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Prevalence of obstructive sleep apnea in suicidal patients with major depressive disorder.Journal of psychiatric research · 2019Trial
- Implementation of a digital obstructive sleep apnoea pathway in a tertiary respiratory service: a prospective service evaluation.Sleep medicine: X · 2026Article
- Obstructive Sleep Apnea Risk and Mental Health Conditions Among Older Canadian Adults in the Canadian Longitudinal Study on Aging.JAMA network open · 2025Article
- Investigating the role of depression in obstructive sleep apnea and predicting risk factors for OSA in depressed patients: machine learning-assisted evidence from NHANES.BMC psychiatry · 2025Article
- Prevalence and risk factors of depression in Korean patients with untreated obstructive sleep apnea.Frontiers in neurology · 2025Article
- Obstructive sleep apnea and mental disorders: a bidirectional mendelian randomization study.BMC psychiatry · 2024Article
- A Narrative Review of Self-Reported Scales to Evaluate Depression and Anxiety Symptoms in Adult Obstructive Sleep Apnea Patients.Medicina (Kaunas, Lithuania) · 2024Review
- Association of Short Sleep Duration and Obstructive Sleep Apnea with Central Obesity: A Retrospective Study Utilizing Anthropometric Measures.Nature and science of sleep · 2024Article
- Assessing the causal relationship between psychiatric disorders and obstructive sleep apnea: a bidirectional Mendelian randomization.Frontiers in psychiatry · 2024Article
- Poor sleep Quality and Obstructive Sleep Apnea are Associated with Maternal Mood, and Anxiety Disorders in Pregnancy.Maternal and child health journal · 2022Article
- Bidirectional relationships of comorbidity with obstructive sleep apnoea.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Comorbid Major Depressive Disorder and Obstructive Sleep Apnea.Case reports in psychiatry · 2022Article
- Associations of Depression, Anxiety, and Life Events With the Risk of Obstructive Sleep Apnea Evaluated by Berlin Questionnaire.Frontiers in medicine · 2022Article
- Characteristics of Patients with Obstructive Sleep Apnea at High Risk for Cardiovascular Disease.Medicina (Kaunas, Lithuania) · 2021Article
- Increased risk of major depressive disorder in sleep apnea patients in Taiwan.Scientific reports · 2021Article
- Positive airway pressure therapy for obstructive sleep apnea in patients with Osteogenesis imperfecta: a prospective pilot study.BMC musculoskeletal disorders · 2021Observational
- Polymorphism of the Serotonin Transporter Gene and the Peripheral 5-Hydroxytryptamine in Obstructive Sleep Apnea: What Do We Know and What are We Looking for? A Systematic Review of the Literature.Nature and science of sleep · 2021Review
- Psychological Distress and Weight Gain in Pregnancy: a Population-Based Study.International journal of behavioral medicine · 2020Article
- The Impact of Antidepressants on the Risk of Developing Obstructive Sleep Apnea in Posttraumatic Stress Disorder: A Nationwide Cohort Study in Taiwan.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Article
- The Association between Health Conditions in World Trade Center Responders and Sleep-Related Quality of Life and Sleep Complaints.International journal of environmental research and public health · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An association may exist between obstructive sleep apnea (OSA) and depression. However, results regarding this association are inconsistent, and the direction of the association between OSA and depression remains unknown. Therefore, we used the Taiwan National Health Insurance Research Database to investigate the bidirectional association between OSA and depression.A total of 6427 OSA patients and 32,135 age and sex-matched control subjects were enrolled to analyze the risk of depression among patients with OSA, where 27,073 patients with depression and 135,365 control subjects were enrolled to address the risk of OSA among patients with depression. All subjects were followed to identify their outcomes of interest from January 1, 1997 to December 31, 2012.Cox proportional-hazards models, after adjusting for potential confounders, demonstrated that patients with OSA had an increased risk (adjusted hazard ratio 2.48, 95% confidence interval 2.20-2.79) of developing depression, whereas those with depression were associated with an increased risk of future OSA (adjusted hazard ratio 2.30, 95% confidence interval 2.11-2.50).Our results suggested that a strong bidirectional relationship exists between OSA and depression, with each disease influencing the development of the other. Health providers are recommended to ensure the early detection and management of depression among patients with OSA and vice versa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.