Evidence map›Paper›PMID 27631219›Full record

ArticleMedicine2016

Cell-free DNA in pregnancy with choriocarcinoma and coexistent live fetus: A case report.

Mona Kjaerboel Kristiansen, Isa Niemann, Jacob Christian Lindegaard, Mette Christiansen, Mette Warming Joergensen, Ida Vogel, Dorte Launholt Lildballe, Lone Sunde

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mona Kjaerboel KristiansenDepartment of Clinical Genetics, Aarhus University Hospital, Aarhus N Department of Gynecology and Obstetrics, Aarhus University Hospital, Aarhus N Department of Oncology, Aarhus University Hospital, Aarhus C Department of Clinical Immunology, Aarhus University Hospital, Aarhus N Institute of Pathology, Aarhus University Hospital, Aarhus C Department of Biomedicine, Aarhus University, Aarhus C, Denmark.
Isa Niemann
Jacob Christian Lindegaard
Mette Christiansen
Mette Warming Joergensen
Ida Vogel
Dorte Launholt Lildballe
Lone Sunde

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis case report describes the use of analysis of cell-free DNA in the blood of a patient with a pregnancy with one live fetus and a choriocarcinoma diagnosed at 22 weeks of gestation.

resultsThe result of the analysis of 16 microsatellite loci on 14 chromosomes in the cell-free DNA in plasma was consistent with the result of the analysis of a tumor biopsy indicating biparental diploid origin of the genome. The DNA markers were discordant with the markers of the placenta indicating two separate conceptions.

conclusionOur results indicate that analysis of cell-free DNA in plasma allows determination of the origin of a choriocarcinoma without tissue biopsy, even in the presence of a co-existent pregnancy.

Indexed as

AdultChoriocarcinomaDNAFemaleHumansLive BirthPregnancyDNA

Identifiers

PMID27631219
PMCPMC5402562

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.