Trial reportMedicine2016
Effects of bovine colostrum on recurrent respiratory tract infections and diarrhea in children.
Trial report in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03801317 (The Effect of Bovine Colostrum/ Egg Supplementation in Young Malawian Children), which is not on this map. Cited by 22 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Bovine Colostrum/ Egg Supplementation in Young Malawian Children
Who cites it
22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Pooled it
- Therapeutics effects of bovine colostrum applications on gastrointestinal diseases: a systematic review.Systematic reviews · 2024Pooled it
- Effect of Lactoferrin Supplementation on Inflammation, Immune Function, and Prevention of Respiratory Tract Infections in Humans: A Systematic Review and Meta-analysis.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Pooled it
- Bovine colostrum and product intervention associated with relief of childhood infectious diarrhea.Scientific reports · 2019Pooled it
- Trial
- Trial
- Bovine colostrum for prevention of recurrent urinary tract infections in susceptible children: A randomized controlled trial.World journal of clinical pediatrics · 2026Article
- Bovine Colostrum in Pediatric Nutrition and Health.Nutrients · 2024Review
- Review
- Exploring the Potential Benefits of Bovine Colostrum Supplementation in the Management of Diabetes and its Complications: A Comprehensive Review.Current diabetes reviews · 2024Review
- The Study of Yak Colostrum Nutritional Content Based on Foodomics.Foods (Basel, Switzerland) · 2023Article
- Colostrum Proteins in Protection against Therapy-Induced Injuries in Cancer Chemo- and Radiotherapy: A Comprehensive Review.Biomedicines · 2023Review
- Article
- Bovine colostrum and its potential contributions for treatment and prevention of COVID-19.Frontiers in immunology · 2023Review
- Prophylactic Effect of Bovine Colostrum on Intestinal Microbiota and Behavior in Wild-Type and Zonulin Transgenic Mice.Biomedicines · 2022Article
- Bioactive compounds, nutritional profile and health benefits of colostrum: a review.Food production, processing and nutrition · 2022Review
- Colostrum Therapy for Human Gastrointestinal Health and Disease.Nutrients · 2021Review
- Bovine Colostrum: Its Constituents and Uses.Nutrients · 2021Review
- Regulation Effect of a Chinese Herbal Formula on Flora and Mucosal Immune Secretory Immunoglobulin A in Rats.Evidence-based complementary and alternative medicine : eCAM · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBovine colostrum (BC) has direct antimicrobial and endotoxin-neutralizing effects throughout the alimentary tract, as well as other bioactivities that suppress gut inflammation and promote mucosal integrity and tissue repair under various conditions related to tissue injury. The precise role of BC in respiratory and gastrointestinal (GI) infections in children is not well defined. The aim of this study was to evaluate the efficacy and tolerability of BC administration in preventing recurrent upper respiratory tract infections (URTI) and diarrhea in children.
methodsOne hundred sixty children (aged 1-6 years) having recurrent episodes of URTI or diarrhea received BC for 4 weeks. The number of episodes of URTI, diarrhea, and frequency of hospitalization required for URTI and diarrhea occurring during the study period were assessed at weeks 8 and 24.
resultsFrom a total number of 160 children, 81 patients (50.63%) were males. The mean age (± SD) was 3.65 (± 2.01) years. The mean (± SD) total number of infections was significantly decreased after BC therapy from 8.6 ± 5.1 at baseline to 5.5 ± 1.2 after 2 months (P < 0.001) and to 5.7 ± 1.6 after 6 months (P < 0.001). The mean (± SD) total number of URTI (P < 0.0001), number of episodes of diarrhea (P < 0.001), and number of hospital admissions (P < 0.001) were significantly decreased after BC therapy.
conclusionBC is effective in the prophylaxis of recurrent URTI and diarrhea as it reduces the number of episodes and the hospitalization due to these infections. Results of this study suggest that BC could be provided as a therapeutic option for children with recurrent URTI and diarrhea.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.