Evidence map›Paper›PMID 27630945›Full record

ArticleJournal of clinical and diagnostic research : JCDR2016

Minor Salivary Gland Changes in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma - A Histopathological Study.

Sunil Paramel Mohan, Ravi Teja Chitturi, Yoithapprabhunath Thukanayakanpalayam Ragunathan, Suman Jhansi Lakshmi, Jaisanghar Nallusamy, Isaac Joseph

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and diagnostic research : JCDR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Effect of ethanol extract fromOpen veterinary journal · 2023
    Article
  4. Parenchymal changes of salivary glands adjacent to a variety of salivary gland disorders.International journal of clinical and experimental pathology · 2019
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sunil Paramel MohanHead of Department, Deparment of Oral Pathology, Director, Department of Stem Cells and Regenerative Medicine, Dean, Sree Anjaneya Institute of Dental Sciences , Calicut, Kerala, India .
Ravi Teja ChitturiLecturer, Department of Oral Biology, School of Dentistry, Faculty of Medical Sciences, The University of the West Indies , St. Augustine Campus, Trinidad and Tobago .
Yoithapprabhunath Thukanayakanpalayam RagunathanReader, Department of Oral and Maxillofacial Pathology, Vivekanandha Dental College for Women , Tamilnadu, India .
Suman Jhansi LakshmiProfessor, Department of Oral Medicine and Radiology, K S R Institute of Dental Science and Research , Tiruchengode, Tamilnadu, India .
Jaisanghar NallusamyProfessor, Department of Oral Medicine and Radiology, Sree Anjaneya Institute of Dental Sciences , Calicut, Kerala, India .
Isaac JosephProfessor and Head, Department of Oral Pathology, Sree Moogambigai Dental College , Kulasekharam, Tamil Nadu, India .
Regenerative Medicine Institute · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe most common etiology for Oral Squamous Cell Carcinoma (OSCC) is tobacco and tobacco related products which cause nuclear damage to the keratinocytes. The chemical carcinogens not only affect the lining of oral epithelium but also affect the lining epithelium of the excretory ducts of the salivary glands. Thus, there is a possibility of epithelial dysplasia of the salivary duct epithelium which may lead to potential malignant transformation.

aimThe study was performed to see the changes in the minor salivary glands and excretory ducts in cases of oral epithelial dysplasia and OSCC. MATERIALS AND

methodsA total of 278 archival cases of mild, moderate and severe epithelial dysplasia, carcinoma in situ, OSCC including verrucous carcinoma were histopathologically evaluated to observe changes in the excretory ducts and the minor salivary glands.

resultsIn the study there were 56.5% males and 43.5% females. The age group that was most commonly affected in both the sexes was 50-60 yr old. Buccal mucosa was the most common site of involvement. Ductal changes observed in the excretory duct include simple hyperplasia, metaplastic changes such as mucous, oncocytic & squamous, and infiltration of inflammatory cells and malignant cells. Acinar changes observed were degeneration, squamous metaplasia, myoepithelial cell proliferation and inflammatory cell infiltration. Both the excretory ducts and ducts within the gland showed dysplasia.

conclusionAccording to observations in our study it is suggested that histopathological interpretation for oral mucosal lesions especially oral epithelial dysplasias and OSCC should also include changes related to salivary gland tissue to provide a better treatment plan and prevent recurrence of the malignant tumours.

Indexed as

Acinar changesExcretory ductHyperplasiaMetaplasiaSalivary gland tumour

Identifiers

PMID27630945
PMCPMC5020236
OpenAlexW2514816878

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.