ReviewOxidative medicine and cellular longevity2016
Mitochondria in the Aging Muscles of Flies and Mice: New Perspectives for Old Characters.
Review in Oxidative medicine and cellular longevity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Fine-tuning striated muscle performance: conserved sarcomere-level mechanisms across insect and vertebrate systems.Frontiers in physiology · 2026Review
- Xanthoxyline prevents aging and neuronal damage by activating autophagy and DAF-16 expression inAnimal cells and systems · 2025Article
- Protective Role ofParkinson's disease · 2023Article
- Protective Effect of Delta-Like 1 Homolog Against Muscular Atrophy in a Mouse Model.Endocrinology and metabolism (Seoul, Korea) · 2022Article
- Progressive reorganization of mitochondrial apparatus in aging skeletal muscle of naked mole rats (Aging · 2021Article
- Assessing the Potential of Nutraceuticals as Geroprotectors on Muscle Performance and Cognition in Aging Mice.Antioxidants (Basel, Switzerland) · 2021Article
- Coordination of tumor growth and host wasting by tumor-derived Upd3.Cell reports · 2021Article
- Lifelong Aerobic Exercise Alleviates Sarcopenia by Activating Autophagy and Inhibiting Protein Degradation via the AMPK/PGC-1α Signaling Pathway.Metabolites · 2021Article
- Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster.Nature communications · 2020Article
- Mechanism of increased risk of insulin resistance in aging skeletal muscle.Diabetology & metabolic syndrome · 2020Review
- Hexose Potentiates Peptide-Conjugated Morpholino Oligomer Efficacy in Cardiac Muscles of Dystrophic Mice in an Age-Dependent Manner.Molecular therapy. Nucleic acids · 2019Article
- Phosphatidylcholine Extends Lifespan via DAF-16 and Reduces Amyloid-Beta-Induced Toxicity inOxidative medicine and cellular longevity · 2019Article
- Healthy mitochondria inhibit the metastatic melanoma in lungs.International journal of biological sciences · 2019Article
- Review
- Selenocysteine modulates resistance to environmental stress and confers anti-aging effects in C. elegans.Clinics (Sao Paulo, Brazil) · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sarcopenia is the loss of muscle mass accompanied by a decrease in muscle strength and resistance and is the main cause of disability among the elderly. Muscle loss begins long before there is any clear physical impact in the senior adult. Despite all this, the molecular mechanisms underlying muscle aging are far from being understood. Recent studies have identified that not only mitochondrial metabolic dysfunction but also mitochondrial dynamics and mitochondrial calcium uptake could be involved in the degeneration of skeletal muscle mass. Mitochondrial homeostasis influences muscle quality which, in turn, could play a triggering role in signaling of systemic aging. Thus, it has become apparent that mitochondrial status in muscle cells could be a driver of whole body physiology and organismal aging. In the present review, we discuss the existing evidence for the mitochondria related mechanisms underlying the appearance of muscle aging and sarcopenia in flies and mice.
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