Evidence map›Paper›PMID 27630733›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2016

Immunomodulatory and Antimicrobial Activity of Babassu Mesocarp Improves the Survival in Lethal Sepsis.

Elizabeth S B Barroqueiro, Dayanna S Prado, Priscila S Barcellos, Tonicley A Silva, Wanderson S Pereira, Lucilene A Silva, Márcia C G Maciel, Rodrigo B Barroqueiro, Flávia R F Nascimento, Azizedite G Gonçalves and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Elizabeth S B BarroqueiroCentro de Ciências Biológicas e da Saúde, Laboratorio de Imunofisiologia, Universidade Federal do Maranhão, Cidade Univesitária Dom Delgado, No. 1966, Avenida dos Portugueses, 6080-580 São Luís, MA, Brazil.ORCID 0000-0002-5867-5583
Dayanna S PradoCentro de Ciências Biológicas e da Saúde, Laboratorio de Imunofisiologia, Universidade Federal do Maranhão, Cidade Univesitária Dom Delgado, No. 1966, Avenida dos Portugueses, 6080-580 São Luís, MA, Brazil.
Priscila S BarcellosCentro de Ciências Biológicas e da Saúde, Laboratorio de Imunofisiologia, Universidade Federal do Maranhão, Cidade Univesitária Dom Delgado, No. 1966, Avenida dos Portugueses, 6080-580 São Luís, MA, Brazil.
Tonicley A SilvaCentro de Ciências Biológicas e da Saúde, Laboratorio de Imunofisiologia, Universidade Federal do Maranhão, Cidade Univesitária Dom Delgado, No. 1966, Avenida dos Portugueses, 6080-580 São Luís, MA, Brazil.ORCID 0000-0002-5024-7090
Wanderson S PereiraCentro de Ciências Biológicas e da Saúde, Laboratorio de Imunofisiologia, Universidade Federal do Maranhão, Cidade Univesitária Dom Delgado, No. 1966, Avenida dos Portugueses, 6080-580 São Luís, MA, Brazil.ORCID 0000-0002-6757-6798
Lucilene A SilvaCentro de Ciências Biológicas e da Saúde, Laboratorio de Imunofisiologia, Universidade Federal do Maranhão, Cidade Univesitária Dom Delgado, No. 1966, Avenida dos Portugueses, 6080-580 São Luís, MA, Brazil.ORCID 0000-0001-7708-2196
Márcia C G MacielCentro de Ciências Biológicas e da Saúde, Laboratorio de Imunofisiologia, Universidade Federal do Maranhão, Cidade Univesitária Dom Delgado, No. 1966, Avenida dos Portugueses, 6080-580 São Luís, MA, Brazil.ORCID 0000-0001-8782-4923
Rodrigo B BarroqueiroCentro de Ciências Biológicas e da Saúde, Laboratorio de Imunofisiologia, Universidade Federal do Maranhão, Cidade Univesitária Dom Delgado, No. 1966, Avenida dos Portugueses, 6080-580 São Luís, MA, Brazil.ORCID 0000-0001-5367-0620
Flávia R F NascimentoCentro de Ciências Biológicas e da Saúde, Laboratorio de Imunofisiologia, Universidade Federal do Maranhão, Cidade Univesitária Dom Delgado, No. 1966, Avenida dos Portugueses, 6080-580 São Luís, MA, Brazil.ORCID 0000-0001-9328-1806
Azizedite G GonçalvesCentro de Ciências Biológicas e da Saúde, Laboratorio de Imunofisiologia, Universidade Federal do Maranhão, Cidade Univesitária Dom Delgado, No. 1966, Avenida dos Portugueses, 6080-580 São Luís, MA, Brazil.
Rosane N M GuerraCentro de Ciências Biológicas e da Saúde, Laboratorio de Imunofisiologia, Universidade Federal do Maranhão, Cidade Univesitária Dom Delgado, No. 1966, Avenida dos Portugueses, 6080-580 São Luís, MA, Brazil.ORCID 0000-0002-9865-9262
Universidade Federal do Maranhão · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Attalea speciosa syn Orbignya phalerata Mart. (babassu) has been used in the treatment of inflammatory and infectious diseases. Aim of the study. To investigate the antimicrobial and immunological activity of babassu mesocarp extract (EE). Material and Methods. The in vitro antimicrobial activity was evaluated by disk diffusion assay and by determination of the minimum inhibitory concentration (MIC) to Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus, and methicillin-resistant Staphylococcus aureus (MRSA). The flavonoids and phenolic acids content were determined by chromatography. The in vivo assays were performed in Swiss mice submitted to sepsis by cecal ligation and puncture (CLP). The mice received EE subcutaneously (125 or 250 mg/Kg), 6 hours after the CLP. The number of lymphoid cells was quantified and the cytokines production was determined by ELISA after 12 h. Results. EE was effective as antimicrobial to E. faecalis, S. aureus, and MRSA. EE is rich in phenolic acids, a class of compounds with antimicrobial and immunological activity. An increased survival can be observed in those groups, possibly due to a significant inhibition of TNF-α and IL-6. Conclusions. The EE showed specific antimicrobial activity in vitro and an important antiseptic effect in vivo possibly due to the antimicrobial and immunomodulatory activity.

Identifiers

PMID27630733
PMCPMC5007311
OpenAlexW2514452971

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.