Evidence map›Paper›PMID 27630727›Full record

ArticleHepatitis monthly2016

The Prevalence of Hepatitis C Virus Core Amino Acid 70 Substitution and Genotypes of Polymorphisms Near the IFNL3 Gene in Iranian Patients With Chronic Hepatitis C.

Danesh Kadjbaf, Maryam Keshvari, Seyed Moayed Alavian, Ali Pouryasin, Bita Behnava, Shima Salimi, Leila Mehrnoush, Pegah Karimi Elizee, Heidar Sharafi

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Article in Hepatitis monthly, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Danesh KadjbafBaqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, IR Iran; School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, IR Iran.
Maryam KeshvariBlood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, IR Iran.
Seyed Moayed AlavianBaqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, IR Iran; Middle East Liver Disease (MELD) Center, Tehran, IR Iran.
Ali PouryasinArmin Pathobiology Laboratory, Tehran, IR Iran; Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, IR Iran.
Bita BehnavaBaqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, IR Iran; Middle East Liver Disease (MELD) Center, Tehran, IR Iran.
Shima SalimiBaqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, IR Iran; Middle East Liver Disease (MELD) Center, Tehran, IR Iran.
Leila MehrnoushBaqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, IR Iran; Middle East Liver Disease (MELD) Center, Tehran, IR Iran.
Pegah Karimi ElizeeMiddle East Liver Disease (MELD) Center, Tehran, IR Iran.
Heidar SharafiBaqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, IR Iran; Middle East Liver Disease (MELD) Center, Tehran, IR Iran; Armin Pathobiology Laboratory, Tehran, IR Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMolecular studies have demonstrated that the hepatitis C virus (HCV) genotype and host genetics play predictive roles in the management of patients infected with HCV.

objectivesThis study aimed to investigate the HCV genotype, core amino acid (aa) 70 substitution, and polymorphisms near the IFNL3 gene (including rs12979860 and rs8099917) among Iranian patients with chronic hepatitis C (CHC). PATIENTS AND

methodsIn this cross-sectional study, the molecular profiles of the HCV genotype, core aa 70 substitution, and rs12979860 and rs8099917 polymorphisms and plasma HCV RNA levels were determined in 429 CHC patients including 141 hemophilic, 84 thalassemic, and 204 non-hemophilic, non-thalassemic patients.

resultsThe hepatitis C virus subtype 1a was the most common subtype in the study population. Core aa substitution Arg70Gln was strongly associated with cirrhosis (OR = 2.49; 95% CI = 1.13 - 5.50; P = 0.020). Core aa 70 substitutions were more frequently observed in patients with the HCV subtype 1b than in patients with any other HCV subtypes (P < 0.001). Core aa 70 substitutions were also more common in patients with the rs12979860 TT genotype than in patients with non-TT genotypes (17.3% vs. 8.5%, P = 0.022) and also in rs8099917 non-TT genotypes than in the TT genotype (14.0% vs. 7.0%, P = 0.026). The HCV genotypes and rs8099917 polymorphisms were correlated in which HCV subtype 1b was in favor of rs8099917 GG and HCV subtype 3a favored rs8099917 TT (P = 0.021). Furthermore, the rs12979860 TT and rs8099917 GG genotypes showed significantly lower HCV RNA levels than the other genotypes (P < 0.001).

conclusionsThere is an as yet unexplained association between HCV and host parameters with unknown mechanisms in patients with chronic HCV infection. The assessments of core aa 70 substitution and polymorphisms near the IFNL3 gene could offer promising steps to improve the management of patients with HCV.

Indexed as

Chronic hepatitis CHCV GenotypesHemophiliaIFN-Lambda-3 ProteinThalassemiaViral Core Protein

Identifiers

PMID27630727
PMCPMC5010881

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