ArticleNeural regeneration research2016
Differential temporal expression of matrix metalloproteinases following sciatic nerve crush.
Article in Neural regeneration research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Regional Microglial Response in Entorhino-Hippocampal Slice Cultures to Schaffer Collateral Lesion and Metalloproteinases Modulation.International journal of molecular sciences · 2024Article
- Chemokine platelet factor 4 accelerates peripheral nerve regeneration by regulating Schwann cell activation and axon elongation.Neural regeneration research · 2024Article
- Type I collagen extracellular matrix facilitates nerve regeneration via the construction of a favourable microenvironment.Burns & trauma · 2024Article
- M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast-Schwann cell-signaling relay.Journal of neuroinflammation · 2023Article
- Prospects of Using Chitosan-Based Biopolymers in the Treatment of Peripheral Nerve Injuries.International journal of molecular sciences · 2023Review
- A Matrix Metalloproteinase Mediates Tracheal Development inInternational journal of molecular sciences · 2021Article
- Sequencing analysis of matrix metalloproteinase 7-induced genetic changes in Schwann cells.Neural regeneration research · 2020Article
- Targeting the blood-nerve barrier for the management of immune-mediated peripheral neuropathies.Experimental neurology · 2020Review
- Matrix metalloproteinase 7 promoted Schwann cell migration and myelination after rat sciatic nerve injury.Molecular brain · 2019Article
- Variation in expression of small ubiquitin-like modifiers in injured sciatic nerve of mice.Neural regeneration research · 2019Article
- Transcriptome analysis of adherens junction pathway-related genes after peripheral nerve injury.Neural regeneration research · 2018Article
- A Hydroxypyrone-Based Inhibitor of Metalloproteinase-12 Displays Neuroprotective Properties in BothInternational journal of molecular sciences · 2018Article
- Peripheral Nerve Injury Induces Dynamic Changes of Tight Junction Components.Frontiers in physiology · 2018Article
- Actin Cytoskeleton Affects Schwann Cell Migration and Peripheral Nerve Regeneration.Frontiers in physiology · 2018Article
- A comparative study of effect of autograft compared with allograft anterior cruciate ligament reconstruction on expressions ofBioscience reports · 2017Article
- Peripheral denervation participates in heterotopic ossification in a spinal cord injury model.PloS one · 2017Article
- Ingenuity Pathway Analysis of Gene Expression Profiles in Distal Nerve Stump following Nerve Injury: Insights into Wallerian Degeneration.Frontiers in cellular neuroscience · 2016Article
- Targeting Matrix Metalloproteinases: A Potential Strategy for Improving Cell Transplantation for Nervous System Repair.Cell transplantationArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously performed transcriptome sequencing and found that genes for matrix metalloproteinases (MMPs), such as MMP7 and 12, seem to be highly upregulated following peripheral nerve injury, and may be involved in nerve repair. In the present study, we systematically determined the expression levels of MMPs and their regulators at 1, 4, 7 and 14 days after sciatic nerve crush injury. The number of differentially expressed genes was elevated at 4 and 7 days after injury, but decreased at 14 days after injury. Among the differentially expressed genes, those most up-regulated showed fold changes of more than 214, while those most down-regulated exhibited fold changes of more than 2-10. Gene sequencing showed that, at all time points after injury, a variety of MMP genes in the "Inhibition of MMPs" pathway were up-regulated, and their inhibitor genes were down-regulated. Expression of key up- and down-regulated genes was verified by quantitative real-time polymerase chain reaction analysis and found to be consistent with transcriptome sequencing. These results suggest that MMP-related genes are strongly involved in the process of peripheral nerve regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.