ArticleNeural regeneration research2016
Protective effects of ginsenoside Rg1 against hydrogen peroxide-induced injury in human neuroblastoma cells.
Article in Neural regeneration research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Ginsenoside Rg1 improves anti-tumor efficacy of adoptive cell therapy by enhancing T cell effector functions.Blood science (Baltimore, Md.) · 2023Article
- Alfalfa saponins inhibit oxidative stress-induced cell apoptosis through the MAPK signaling pathway.Redox report : communications in free radical research · 2022Article
- [Effect of hot water extract of Korean ginseng on neuroblastoma cell parthanatos].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Antioxidant Effects of Oleuropein on Hydrogen Peroxide-Induced Neuronal Stress- AnAnti-inflammatory & anti-allergy agents in medicinal chemistry · 2020Article
- Neuroprotective Effects of Ginseng Phytochemicals: Recent Perspectives.Molecules (Basel, Switzerland) · 2019Review
- Review
- Treatment of glaucomatous optic nerve damage using ginsenoside Rg1 mediated by ultrasound targeted microbubble destruction.Experimental and therapeutic medicine · 2018Article
- Ginsenoside Rg1 protects human renal tubular epithelial cells from lipopolysaccharide-induced apoptosis and inflammation damage.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- Neuroprotective Effect of the Ginsenoside Rg1 on Cerebral Ischemic Injury In Vivo and In Vitro Is Mediated by PPAREvidence-based complementary and alternative medicine : eCAM · 2017Article
- Influence of hydrogen-occluding-silica on migration and apoptosis in human esophageal cellsMedical gas researchArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The active ingredient of ginseng, ginsenosides Rg1, has been shown to scavenge free radicals and improve antioxidant capacity. This study hypothesized that ginsenosides Rg1 has a protective role in human neuroblastoma cells injured by H2O2. Ginsenosides Rg1 at different concentrations (50 and 100 μM) was used to treat H2O2 (150 μM)-injured SH-SY5Y cells. Results demonstrated that ginsenoside Rg1 elevated the survival rate of SH-SY5Y cells injured by H2O2, diminished the amount of leaked lactate dehydrogenase, and increased superoxide dismutase activity. Ginsenoside Rg1 effectively suppressed caspase-3 immunoreactivity, and contributed to heat shock protein 70 gene expression, in a dose-dependent manner. These results indicate that ginsenoside Rg1 has protective effects on SH-SY5Y cells injured by H2O2 and that its mechanism of action is associated with anti-oxidation and the inhibition of apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.