Evidence map›Paper›PMID 27630695›Full record

ArticleNeural regeneration research2016

Magnetic resonance diffusion tensor imaging following major ozonated autohemotherapy for treatment of acute cerebral infarction.

Xiao-Na Wu, Tao Zhang, Jun Wang, Xiao-Yan Liu, Zhen-Sheng Li, Wei Xiang, Wei-Qing Du, Hong-Jun Yang, Tie-Gen Xiong, Wen-Ting Deng and 2 more

Abstract read
In one paragraph

Article in Neural regeneration research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
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  7. Article
  8. Application of ozone therapy in interventional medicine.Journal of interventional medicine · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiao-Na WuDepartment of Neurology, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China; Department of Neurology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
Tao ZhangDepartment of Orthopedics, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
Jun WangDepartment of MRI, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
Xiao-Yan LiuDepartment of Neurology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
Zhen-Sheng LiDepartment of Neurology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
Wei XiangDepartment of Neurology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
Wei-Qing DuDepartment of MRI, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
Hong-Jun YangDepartment of Neurology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
Tie-Gen XiongDepartment of Neurology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
Wen-Ting DengDepartment of Neurology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.
Kai-Run PengDepartment of Neurology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China.ORCID 0000-0003-4784-2451
Su-Yue PanDepartment of Neurology, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China.ORCID 0000-0003-2744-1984

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Major ozonated autohemotherapy has been shown to promote recovery of upper limb motor function in patients with acute cerebral infarction, but whether major ozonated autohemotherapy affects remote injury remains poorly understood. Here, we assumed that major ozonated autohemotherapy contributes to recovery of clinical function, possibly by reducing remote injury after acute cerebral infarction. Sixty acute cerebral infarction patients aged 30-80 years were equally and randomly allocated to ozone treatment and control groups. Patients in the ozone treatment group received medical treatment and major ozonated autohemotherapy (47 mg/L, 100 mL ozone) for 10 ± 2 days. Patients in the control group received medical treatment only. National Institutes of Health Stroke Scale score, modified Rankin scale score, and reduced degree of fractional anisotropy values of brain magnetic resonance diffusion tensor imaging were remarkably decreased, brain function improved, clinical efficiency significantly increased, and no obvious adverse reactions detected in the ozone treatment group compared with the control group. These findings suggest that major ozonated autohemotherapy promotes recovery of neurological function in acute cerebral infarction patients by reducing remote injury, and additionally, exhibits high safety.

Indexed as

anisotropycerebral infarctioncerebral pedunclecorticospinal tractdiffusion tensor imaginginternal capsulemagnetic resonancenerve regenerationneural regenerationozonewhite matter

Identifiers

PMID27630695
PMCPMC4994454

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.