ArticleFrontiers in neural circuits2016
Sustained Attentional States Require Distinct Temporal Involvement of the Dorsal and Ventral Medial Prefrontal Cortex.
Article in Frontiers in neural circuits, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Galanin receptor 1 expressing neurons in hippocampal-prefrontal circuitry modulate goal directed attention and impulse control.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- A specific basal forebrain-medial prefrontal cholinergic pathway improves attentional control in male mice.Scientific reports · 2026Article
- Racial Discrimination-Related Interoceptive Network Disruptions: A Pathway to Disconnection.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Medial prefrontal activation as a neural predictor of cognitive training gains in older adults with amnestic mild cognitive impairment: exploratory evidence.Frontiers in aging neuroscience · 2026Article
- Adverse Childhood Experiences Underlie Race-Related Differences in Neural Reactivity to Stress.Behavioural neurology · 2026Article
- Neural activity is altered by childhood trauma exposure and varied by sex in typically developing youths during sustained attention-to-response tasks (SART).Neuropsychologia · 2025Article
- Galanin receptor 1 expressing neurons in hippocampal-prefrontal circuitry modulate goal directed attention and impulse control.bioRxiv : the preprint server for biology · 2025Article
- Distinct neuronal processes in the ventromedial prefrontal cortex mediate changes in attention load and nicotine pro-cognitive effects in male rats.Frontiers in neural circuits · 2025Article
- Dissociable Roles of the mPFC-to-VTA Pathway in the Control of Impulsive Action and Risk-Related Decision-Making in Roman High- and Low-Avoidance Rats.The international journal of neuropsychopharmacology · 2024Article
- Pramipexole restores behavioral inhibition in highly impulsive rats through a paradoxical modulation of frontostriatal networks.Translational psychiatry · 2024Article
- Sex-Dependent Attentional Impairments in a Subchronic Ketamine Mouse Model for Schizophrenia.Biological psychiatry global open science · 2024Article
- Dissection of neuronal circuits underlying sustained attention with the five-choice serial reaction time task.Neuroscience and biobehavioral reviews · 2023Review
- Organization and engagement of a prefrontal-olfactory network during olfactory selective attention.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Parallel Pathways Provide Hippocampal Spatial Information to Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cognitive performance during adulthood in a rat model of neonatal diffuse white matter injury.Psychopharmacology · 2022Article
- Chemogenetic inhibition of prefrontal projection neurons constrains top-down control of attention in young but not aged rats.Brain structure & function · 2021Article
- Control of impulsivity by GCommunications biology · 2021Article
- Bi-directional regulation of cognitive control by distinct prefrontal cortical output neurons to thalamus and striatum.Nature communications · 2021Article
- Stress Regulation of Sustained Attention and the Cholinergic Attention System.Biological psychiatry · 2020Article
- Effects of choice on neuronal activity in anterior cingulate, prelimbic, and infralimbic cortices in the rat: Comparison of serial lever pressing with delayed nonmatching to position.The European journal of neuroscience · 2020Article
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Abstract
Attending the sensory environment for cue detection is a cognitive operation that occurs on a time scale of seconds. The dorsal and ventral medial prefrontal cortex (mPFC) contribute to separate aspects of attentional processing. Pyramidal neurons in different parts of the mPFC are active during cognitive behavior, yet whether this activity is causally underlying attentional processing is not known. We aimed to determine the precise temporal requirements for activation of the mPFC subregions during the seconds prior to cue detection. To test this, we used optogenetic silencing of dorsal or ventral mPFC pyramidal neurons at defined time windows during a sustained attentional state. We find that the requirement of ventral mPFC pyramidal neuron activity is strictly time-locked to stimulus detection. Inhibiting the ventral mPFC 2 s before or during cue presentation reduces response accuracy and hampers behavioral inhibition. The requirement for dorsal mPFC activity on the other hand is temporally more loosely related to a preparatory attentional state, and short lapses in pyramidal neuron activity in dorsal mPFC do not affect performance. This only occurs when the dorsal mPFC is inhibited during the entire preparatory period. Together, our results reveal that a dissociable temporal recruitment of ventral and dorsal mPFC is required during attentional processing.
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