Evidence map›Paper›PMID 27630187›Full record

ArticleClinical medicine & research2016

Dietary Nitrate Acutely and Markedly Increased Exhaled Nitric Oxide in a Cystic Fibrosis Case.

Conor P Kerley, Emma Kilbride, Peter Greally, Basil Elnazir

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Clinical medicine & research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Conor P KerleyPaediatric Respiratory Department, National Children's Hospital, Dublin 24, Ireland conorkerley@gmail.com.
Emma KilbridePaediatric Respiratory Department, National Children's Hospital, Dublin 24, Ireland.
Peter GreallyPaediatric Respiratory Department, National Children's Hospital, Dublin 24, Ireland.
Basil ElnazirPaediatric Respiratory Department, National Children's Hospital, Dublin 24, Ireland.
National Children’s Research Centre · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Airway nitric oxide (NO) is a ubiquitous signaling molecule with bronchoprotective, anti-inflammatory and anti-infective roles. Cystic fibrosis (CF) is a chronic lung condition associated with deceased exhaled NO. Strategies to increase exhaled NO in CF have yielded inconsistent results. A potential new method of increasing systemic NO involves ingestion of dietary, inorganic nitrate which is reduced to nitrite and NO. We present the case of a 12-year-old, athletic boy with CF who demonstrated acute but marked increases in exhaled NO following dietary nitrate consumption compared to placebo.

Indexed as

DietArginineChildCystic FibrosisExhalationHumansInflammationIronMaleNitratesNitric OxideNitritesPlacebosRespiratory Function TestsTreatment OutcomeArginineIronNitratesNitric OxideNitritesPlacebosCystic fibrosisDietary nitrateExhaled nitric oxideNitrite

Identifiers

PMID27630187
PMCPMC5302458
OpenAlexW2523322985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.