Evidence map›Paper›PMID 27630064›Full record

ReviewAmerican journal of physiology. Renal physiology2016

MRI tools for assessment of microstructure and nephron function of the kidney.

Luke Xie, Kevin M Bennett, Chunlei Liu, G Allan Johnson, Jeff Lei Zhang, Vivian S Lee

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in American journal of physiology. Renal physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06884410 (Reproducibility of Multiparametric Renal Magnetic Resonance Imaging on 1.5T MRI Scanners), which is not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06884410 narecruitingnot on this mapstarted 2025, after this paper: background citation

Reproducibility of Multiparametric Renal Magnetic Resonance Imaging on 1.5T MRI Scanners (RESPECT_1.5T Sub-study)

TypeinterventionalSponsorMario Negri Institute for Pharmacological ResearchRan2025 to 2026Enrolled48ConditionsMultiparametric MRIArmsMRI
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Assessment of Acute Kidney Injury using MRI.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Mapping kidney tubule diameter ex vivo by diffusion MRI.American journal of physiology. Renal physiology · 2021
    Article
  10. New imaging tools to measure nephron numberJournal of developmental origins of health and disease · 2021
    Review
  11. Mapping nephron mass in vivo using positron emission tomography.American journal of physiology. Renal physiology · 2021
    Article
  12. Article
  13. Role of sodium-glucose cotransporter 2 inhibition to mitigate diabetic kidney disease risk in type 1 diabetes.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Measuring rat kidney glomerular number and size in vivo with MRI.American journal of physiology. Renal physiology · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Luke XieUtah Center for Advanced Imaging Research, Department of Radiology, University of Utah, Salt Lake City, Utah; lukenxie@gmail.com.ORCID 0000-0002-3712-5558
Kevin M BennettDepartment of Biology, University of Hawaii at Manoa, Honolulu, Hawaii.
Chunlei LiuCenter for In Vivo Microscopy, Department of Radiology, Duke University Medical Center, Durham, North Carolina; and.
G Allan JohnsonCenter for In Vivo Microscopy, Department of Radiology, Duke University Medical Center, Durham, North Carolina; and.
Jeff Lei ZhangUtah Center for Advanced Imaging Research, Department of Radiology, University of Utah, Salt Lake City, Utah.
Vivian S LeeUtah Center for Advanced Imaging Research, Department of Radiology, University of Utah, Salt Lake City, Utah.
University of Utah · USDuke Medical Center · USUniversity of Hawaiʻi at Mānoa · US

Funding

INTEGRATED CENTER FOR IN VIVO MICROSCOPYP41EB015897 · NIBIB · DUKE UNIVERSITY · PI JOHNSON, GEORGE ALLAN · 2012 to 2017
$7.4M
Ultra-Resolution Imaging of Brain Circuitry and its Development in Mental HealthR01MH096979 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI LIU, CHUNLEI · 2013 to 2017
$1.8M
Agilent Direct Drive 9.4T MRS/MRI ConsoleS10OD010683 · OD · DUKE UNIVERSITY · PI JOHNSON, GEORGE ALLAN · 2012 to 2012
$597k
MRI Techniques to Measure Whole-Kidney NephronR21DK091722 · NIDDK · UNIVERSITY OF HAWAII AT MANOA · PI BENNETT, KEVIN M · 2012 to 2013
$399k
NIBIB NIH HHS P41 EB015897NIDDK NIH HHS R21 DK091722NIH HHS S10 OD010683NIMH NIH HHS R01 MH096979
6 · The paper itself

Abstract

MRI can provide excellent detail of renal structure and function. Recently, novel MR contrast mechanisms and imaging tools have been developed to evaluate microscopic kidney structures including the tubules and glomeruli. Quantitative MRI can assess local tubular function and is able to determine the concentrating mechanism of the kidney noninvasively in real time. Measuring single nephron function is now a near possibility. In parallel to advancing imaging techniques for kidney microstructure is a need to carefully understand the relationship between the local source of MRI contrast and the underlying physiological change. The development of these imaging markers can impact the accurate diagnosis and treatment of kidney disease. This study reviews the novel tools to examine kidney microstructure and local function and demonstrates the application of these methods in renal pathophysiology.

Indexed as

AnimalsHumansKidneyKidney DiseasesNephronscationized ferritin agentsgadolinium-based contrast agentglomerular microstructurekidney concentrating mechanismkidney microstructuremagnetic resonance imagingnephron architecturequantitative susceptibility mappingsusceptibility tensor imaging

Identifiers

PMID27630064
PMCPMC5210196
OpenAlexW2520152805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.