Evidence map›Paper›PMID 27630012›Full record

ReviewOral diseases2017

Periodontal and other oral manifestations of immunodeficiency diseases.

M E Peacock, R M Arce, C W Cutler

Abstract readReview
In one paragraph

Review in Oral diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Triggering mouth-resident antiviral CD8Mucosal immunology · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Oral lichen planus: a microbiologist point of view.International microbiology : the official journal of the Spanish Society for Microbiology · 2021
    Review
  16. Article
  17. Effect ofAntibiotics (Basel, Switzerland) · 2021
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

M E PeacockDepartment of Periodontics, The Dental College of Georgia at Augusta University, Augusta, GA, USA.
R M ArceDepartment of Periodontics, The Dental College of Georgia at Augusta University, Augusta, GA, USA.ORCID http://orcid.org/0000-0002-4721-4722
C W CutlerDepartment of Periodontics, The Dental College of Georgia at Augusta University, Augusta, GA, USA.
Augusta University · US

Funding

Oral Pathogens and Dendritic Cell SubsetsR01DE014328 · NIDCR · STATE UNIVERSITY NEW YORK STONY BROOK · PI CUTLER, CHRISTOPHER WILLIAM · 2001 to 2014
$5.1M
Peripheral blood dendritic cells and periodontitisR21DE020916 · NIDCR · STATE UNIVERSITY NEW YORK STONY BROOK · PI CUTLER, CHRISTOPHER WILLIAM · 2011 to 2012
$362k
NIDCR NIH HHS R01 DE014328NIDCR NIH HHS R21 DE020916
6 · The paper itself

Abstract

The list of immunodeficiency diseases grows each year as novel disorders are discovered, classified, and sometimes reclassified due to our ever-increasing knowledge of immune system function. Although the number of patients with secondary immunodeficiencies (SIDs) greatly exceeds those with primary immunodeficiencies (PIDs), the prevalence of both appears to be on the rise probably because of scientific breakthroughs that facilitate earlier and more accurate diagnosis. Primary immunodeficiencies in adults are not as rare as once thought. Globally, the main causes of secondary immunodeficiency are HIV infection and nutritional insufficiencies. Persons with acquired immune disorders such as AIDS caused by the human immunodeficiency virus (HIV) are now living long and fulfilling lives as a result of highly active antiretroviral therapy (HAART). Irrespective of whether the patient's immune-deficient state is a consequence of a genetic defect or is secondary in nature, dental and medical practitioners must be aware of the constant potential for infections and/or expressions of autoimmunity in these individuals. The purpose of this review was to study the most common conditions resulting from primary and secondary immunodeficiency states, how they are classified, and the detrimental manifestations of these disorders on the periodontal and oral tissues.

Indexed as

Acquired Immunodeficiency SyndromeHumansImmunologic Deficiency SyndromesMalnutritionMouth DiseasesPeriodontal Diseasesautoimmune diseaseimmune defectsimmunodeficiencyoral infectionpathologyperiodontium

Identifiers

PMID27630012
PMCPMC5352551
OpenAlexW2519444457

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.