Evidence map›Paper›PMID 27629921›Full record

ArticleNature communications2016

IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses.

Chang-Min Lee, Chuan Hua He, Adel M Nour, Yang Zhou, Bing Ma, Jin Wook Park, Kyung Hee Kim, Charles Dela Cruz, Lokesh Sharma, Mahmoud L Nasr and 3 more

Erratum issued Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04204434 (Biomarkers For Immune Checkpoint Inhibitors), which is not on this map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04204434 completednot on this map

Biomarkers For Immune Checkpoint Inhibitors

Typeobservational_patient_registrySponsorRhode Island HospitalRan2016 to 2024Enrolled119ConditionsAdvanced Cancer, Neoplasms
3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 124 citations in OpenAlex.

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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Chang-Min LeeDepartment of Molecular Microbiology and Immunology, Brown University, 185 Meeting Street, Box G-L, Providence, Rhode Island 02912, USA.
Chuan Hua HeDepartment of Molecular Microbiology and Immunology, Brown University, 185 Meeting Street, Box G-L, Providence, Rhode Island 02912, USA.
Adel M NourDepartment of Molecular Microbiology and Immunology, Brown University, 185 Meeting Street, Box G-L, Providence, Rhode Island 02912, USA.
Yang ZhouDepartment of Molecular Microbiology and Immunology, Brown University, 185 Meeting Street, Box G-L, Providence, Rhode Island 02912, USA.
Bing MaDepartment of Molecular Microbiology and Immunology, Brown University, 185 Meeting Street, Box G-L, Providence, Rhode Island 02912, USA.
Jin Wook ParkDepartment of Molecular Microbiology and Immunology, Brown University, 185 Meeting Street, Box G-L, Providence, Rhode Island 02912, USA.
Kyung Hee KimDivision of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Charles Dela CruzSection of Pulmonary and Critical Care and Sleep Medicine, Department of Medicine, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06520, USA.
Lokesh SharmaSection of Pulmonary and Critical Care and Sleep Medicine, Department of Medicine, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06520, USA.
Mahmoud L NasrDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.
Yorgo ModisDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.ORCID 0000-0002-6084-0429
Chun Geun LeeDepartment of Molecular Microbiology and Immunology, Brown University, 185 Meeting Street, Box G-L, Providence, Rhode Island 02912, USA.ORCID 0000-0002-9514-3658
Jack A EliasDepartment of Molecular Microbiology and Immunology, Brown University, 185 Meeting Street, Box G-L, Providence, Rhode Island 02912, USA.
Brown University · USHarvard University · USYale University · USEmory University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Respiratory Computational Discovery CoreP01HL114501 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHOI, MARY E · 2013 to 2025
$24.9M
YKL-40 in Idiopathic Pulmonary Fibrosis and Kidney TransplantationU01HL108638 · NHLBI · YALE UNIVERSITY · PI ELIAS, JACK A · 2011 to 2014
$2.6M
Host-Pneumococcal Interaction in the LungR01HL126094 · NHLBI · YALE UNIVERSITY · PI DELA CRUZ, CHARLES S · 2015 to 2019
$2.1M
BRP-39/YKL-40 in Th2 Inflammation and AsthmaR01HL093017 · NHLBI · YALE UNIVERSITY · PI ELIAS, JACK A · 2010 to 2013
$1.6M
Chitinase1 as a Biomarker and Therapeutic Target in Scleroderma Lung DiseaseR01HL115813 · NHLBI · BROWN UNIVERSITY · PI LEE, CHUN GEUN · 2014 to 2017
$1.5M
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS P01 HL114501NHLBI NIH HHS R01 HL093017NHLBI NIH HHS R01 HL115813NHLBI NIH HHS R01 HL126094NHLBI NIH HHS U01 HL108638Wellcome Trust 101908Wellcome Trust 101908/Z/13/Z
6 · The paper itself

Abstract

Recent studies demonstrated that chitinase 3-like-1 (Chi3l1) binds to and signals via IL-13Rα2. However, the mechanism that IL-13Rα2 uses to mediate the effects of Chi3l1 has not been defined. Here, we demonstrate that the membrane protein, TMEM219, is a binding partner of IL-13Rα2 using yeast two-hybrid, co-immunoprecipitation, co-localization and bimolecular fluorescence complementation assays. Furthermore, fluorescence anisotropy nanodisc assays revealed a direct physical interaction between TMEM219 and IL-13Rα2-Chi3l1 complexes. Null mutations or siRNA silencing of TMEM219 or IL-13Rα2 similarly decreased Chi3l1-stimulated epithelial cell HB-EGF production and macrophage MAPK/Erk and PKB/Akt activation. Null mutations of TMEM219 or IL-13Rα2 also phenocopied one another as regards the ability of Chi3l1 to inhibit oxidant-induced apoptosis and lung injury, promote melanoma metastasis and stimulate TGF-β1. TMEM219 also contributed to the decoy function of IL-13Rα2. These studies demonstrate that TMEM219 plays a critical role in Chi3l1-induced IL-13Rα2 mediated signalling and tissue responses.

Indexed as

AnimalsApoptosisCell Line, TumorChitinase-3-Like Protein 1Heparin-binding EGF-like Growth FactorHumansInterleukin-13 Receptor alpha2 SubunitLung InjuryLung NeoplasmsMAP Kinase Signaling SystemMelanoma, ExperimentalMembrane ProteinsMice, Inbred C57BLNeoplasm MetastasisProto-Oncogene Proteins c-aktTransforming Growth Factor beta1CHI3L1 protein, humanChitinase-3-Like Protein 1Heparin-binding EGF-like Growth FactorInterleukin-13 Receptor alpha2 SubunitMembrane ProteinsProto-Oncogene Proteins c-aktTgfb1 protein, mouseTMEM219 protein, humanTmem219 protein, mouseTransforming Growth Factor beta1

Identifiers

PMID27629921
PMCPMC5027616
OpenAlexW2520684171

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.