ArticleJournal of clinical microbiology2016
Clinical Significance of Commensal Gram-Positive Rods Routinely Isolated from Patient Samples.
Article in Journal of clinical microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 83 citations in OpenAlex.
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- Metagenomic Insights into Microbial Signatures in Thrombi from Acute Ischemic Stroke Patients Undergoing Endovascular Treatment.Brain sciences · 2025Article
- Polymicrobial urine cultures: reconciling contamination with the urobiome while recognizing the pathogens.Frontiers in cellular and infection microbiology · 2025Review
- When less is more: the art of communicating clinical microbiology results.Journal of clinical microbiology · 2024Article
- Preanalytical, Analytical and Postanalytical Analyses onDiagnostics (Basel, Switzerland) · 2024Article
- Laboratory approaches to determining blood culture contamination rates: an ASM Laboratory Practices Subcommittee report.Journal of clinical microbiology · 2024Review
- Polymicrobial infections with specificJournal of oral microbiology · 2024Review
- Next Steps: Studying Diabetic Foot Infections with Next-Generation Molecular Assays.Current infectious disease reports · 2023Article
- Patient predictors of pathogenic versus commensal Gram-positive bacilli organisms isolated from blood cultures.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- Beyond the usual suspects: emerging uropathogens in the microbiome age.Frontiers in urology · 2023Review
- Comparative genomic analyses of the clinically-derivedFrontiers in microbiology · 2023Article
- A case series ofJournal of cardiology cases · 2022Article
- Commentary: Can Automated Blood Culture Systems Be Both New and Improved?Journal of clinical microbiology · 2022Article
- Rice leaf endophyticFrontiers in microbiology · 2022Article
- Multidrug-ResistantInternational medical case reports journal · 2022Article
- Commensal Bacteria in the Cystic Fibrosis Airway Microbiome ReduceFrontiers in cellular and infection microbiology · 2022Article
- Article
- Practical Guidance for Clinical Microbiology Laboratories: Diagnosis of Ocular Infections.Clinical microbiology reviews · 2021Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Commensal bacteria from the skin and mucosal surfaces are routinely isolated from patient samples and considered contaminants. The majority of these isolates are catalase-positive Gram-positive rods from multiple genera routinely classified as diphtheroids. These organisms can be seen upon Gram staining of clinical specimens or can be isolated as the predominant or pure species in culture, raising a priori suspicion of a possible involvement in infection. With the development and adoption of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), suspicious isolates are now routinely identified to the species level. In this study, we performed a retrospective data review (2012 to 2015) and utilized site-specific laboratory criteria and chart reviews to identify species within the diphtheroid classification representative of true infection versus contamination. Our data set included 762 isolates from 13 genera constituting 41 bacterial species. Only 18% represented true infection, and 82% were deemed contaminants. Clinically significant isolates were identified in anaerobic wounds (18%), aerobic wounds (30%), blood (5.5%), urine (22%), cerebrospinal fluid (24%), ophthalmologic cultures (8%), and sterile sites (20%). Organisms deemed clinically significant included multiple Actinomyces species in wounds, Propionibacterium species in joints and cerebrospinal fluid associated with central nervous system hardware, Corynebacterium kroppenstedtii (100%) in breast, and Corynebacterium striatum in multiple sites. Novel findings include clinically significant urinary tract infections by Actinomyces neuii (21%) and Corynebacterium aurimucosum (21%). Taken together, these findings indicate that species-level identification of diphtheroids isolated with a priori suspicion of infection is essential to accurately determine whether an isolate belongs to a species associated with specific types of infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.