ArticleJournal of clinical microbiology2016
Whole-Genome Multilocus Sequence Typing of Extended-Spectrum-Beta-Lactamase-Producing Enterobacteriaceae.
Article in Journal of clinical microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- Emergence of multidrug resistant Enterobacter spp. in Nigeria: a genomic study.World journal of microbiology & biotechnology · 2026Article
- Emergence and Dissemination of NDM+OXA-48-like Co-ProducingAntibiotics (Basel, Switzerland) · 2026Article
- TheInternational journal of molecular sciences · 2026Review
- Genomic Characterization and Antimicrobial Resistance Profile ofAntibiotics (Basel, Switzerland) · 2025Article
- One day in Denmark: whole-genome sequence-based analysis of Escherichia coli isolates from clinical settings.The Journal of antimicrobial chemotherapy · 2025Article
- Genomic epidemiology and resistome dynamics ofFrontiers in microbiology · 2025Article
- Molecular Characterization of Multidrug-Resistant and Hypervirulent New Delhi Metallo-Beta-LactamaseAntibiotics (Basel, Switzerland) · 2024Article
- One decade of point-prevalence surveys for carriage of extended-spectrum beta-lactamase-producing enterobacterales: whole genome sequencing based prevalence and genetic characterization in a large Dutch teaching hospital from 2013 to 2022.Antimicrobial resistance and infection control · 2024Article
- Screening ofAntibiotics (Basel, Switzerland) · 2024Article
- Assessment of three antibiotic combination regimens against Gram-negative bacteria causing neonatal sepsis in low- and middle-income countries.Nature communications · 2024Article
- Automating the Illumina DNA library preparation kit for whole genome sequencing applications on the flowbot ONE liquid handler robot.Scientific reports · 2024Article
- One Health surveillance of colistin-resistant Enterobacterales in Belgium and the Netherlands between 2017 and 2019.PloS one · 2024Article
- Phylogenetic lineages and antimicrobial resistance determinants of clinicalMicrobiology spectrum · 2023Article
- Plasmid-mediated colistin resistance from fresh meat and slaughtered animals in the Czech Republic: nation-wide surveillance 2020-2021.Microbiology spectrum · 2023Article
- Comparing antimicrobial resistant genes and phenotypes across multiple sequencing platforms and assays for Enterobacterales clinical isolates.BMC microbiology · 2023Article
- Phylodynamics Uncovers the Transmission of Antibiotic-ResistantbioRxiv : the preprint server for biology · 2023Article
- The role of plasmids in carbapenem resistant E. coli in Alameda County, California.BMC microbiology · 2023Article
- Integrated surveillance of extended-spectrum beta-lactamase (ESBL)-producingEpidemiology and infection · 2022Article
- Next-Generation Sequencing of Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Longitudinal Study on Extended-Spectrum Beta-Lactamase-Microorganisms · 2022Article
1 more citing papers are in PubMed but not listed here.
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8 authors.
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Abstract
Molecular typing has become indispensable in the detection of nosocomial transmission of bacterial pathogens and the identification of sources and routes of transmission in outbreak settings, but current methods are labor-intensive, are difficult to standardize, or have limited resolution. Whole-genome multilocus sequence typing (wgMLST) has emerged as a whole-genome sequencing (WGS)-based gene-by-gene typing method that may overcome these limitations and has been applied successfully for several species in outbreak settings. In this study, genus-, genetic-complex-, and species-specific wgMLST schemes were developed for Citrobacter spp., the Enterobacter cloacae complex, Escherichia coli, Klebsiella oxytoca, and Klebsiella pneumoniae and used to type a national collection of 1,798 extended-spectrum-beta-lactamase-producing Enterobacteriaceae (ESBL-E) isolates obtained from patients in Dutch hospitals. Genus-, genetic-complex-, and species-specific thresholds for genetic distance that accurately distinguish between epidemiologically related and unrelated isolates were defined for Citrobacter spp., the E. cloacae complex, E. coli, and K. pneumoniae wgMLST was shown to have higher discriminatory power and typeability than in silico MLST. In conclusion, the wgMLST schemes developed in this study facilitate high-resolution WGS-based typing of the most prevalent ESBL-producing species in clinical practice and may contribute to further elucidation of the complex epidemiology of antimicrobial-resistant Enterobacteriaceae wgMLST opens up possibilities for the creation of a Web-accessible database for the global surveillance of ESBL-producing bacterial clones.
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