Evidence map›Paper›PMID 27629887›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2016

Mice lacking β-carotene-15,15'-dioxygenase exhibit reduced serum testosterone, prostatic androgen receptor signaling, and prostatic cellular proliferation.

Joshua W Smith, Nikki A Ford, Jennifer M Thomas-Ahner, Nancy E Moran, Eric C Bolton, Matthew A Wallig, Steven K Clinton, John W Erdman

Abstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Joshua W SmithDivision of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Nikki A FordDivision of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Jennifer M Thomas-AhnerComprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
Nancy E MoranComprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
Eric C BoltonDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Matthew A WalligDivision of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Steven K ClintonComprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
John W ErdmanDivision of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois; jwerdman@illinois.edu.
University of Illinois Urbana-Champaign · USThe Ohio State University · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Tomatoes, Lycopene, and Prostate Carcinogenesis in MiceR01CA125384 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ERDMAN, JOHN W · 2007 to 2011
$1.4M
Mechanisms of Carotenoid Transport and Interactions with Nutrient AbsorptionR00AT008576 · NCCIH · BAYLOR COLLEGE OF MEDICINE · PI MORAN, NANCY E · 2017 to 2019
$747k
Mechanisms of Carotenoid Transport and Interactions with Nutrient AbsorptionK99AT008576 · NCCIH · OHIO STATE UNIVERSITY · PI MORAN, NANCY E · 2015 to 2016
$125k
NCCIH NIH HHS K99 AT008576NCCIH NIH HHS R00 AT008576NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA125384
6 · The paper itself

Abstract

β-Carotene-15,15'-dioxygenase (BCO1) cleaves dietary carotenoids at the central 15,15' double bond, most notably acting on β-carotene to yield retinal. However, Bco1 disruption also impacts diverse physiological end points independent of dietary carotenoid feeding, including expression of genes controlling androgen metabolism. Using the Bco1

Indexed as

Animalsbeta-Carotene 15,15'-MonooxygenaseCell ProliferationDown-RegulationMaleMiceMice, Inbred C57BLMice, KnockoutOrgan SizeProstateReceptors, AndrogenSignal TransductionTestosteronebeta-Carotene 15,15'-MonooxygenaseReceptors, AndrogenTestosteroneandrogenBco1carotenoid oxygenaseprostate

Identifiers

PMID27629887
PMCPMC5256971
OpenAlexW2519632915

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.