ArticleJournal of cancer research and clinical oncology2017
Liver tumor boundaries identified intraoperatively using real-time indocyanine green fluorescence imaging.
Article in Journal of cancer research and clinical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Intraoperative fluorescence imaging with indocyanine green in hepatic resection for malignancy: a systematic review and meta-analysis of diagnostic test accuracy studies.Surgical endoscopy · 2020Pooled it
- Testing the Use of Indocyanine Green Fluorescence Image-Guidance in Patients with Liver Surgery Compared To Patients with Standard Liver Surgery: A Feasibility Randomised Controlled Trial.Journal of fluorescence · 2026Trial
- Optimizing indocyanine green positive staining with total liver volume-normalized dosing in robotic hepatectomy: an image-based analysis.Journal of robotic surgery · 2025Observational
- Review
- Case Report: Selective hepatic resection guided by indocyanine green short-wave infrared fluorescence imaging in a dog with multifocal liver lesions.Frontiers in veterinary science · 2025Article
- Article
- An indocyanine green-based liquid biopsy test for circulating tumor cells for pediatric liver cancer.Hepatology communications · 2024Article
- Fluorescence-guided minimally-invasive resection of abdominal paragangliomas using indocyanine green.Scientific reports · 2024Article
- Anatomical liver resection using the ultrasound-guided compression technique in minimal access surgery.Surgical endoscopy · 2024Article
- Indocyanine Green Fluorescence-Guided Surgery for Gastrointestinal Tumors: A Systematic Review.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2022Review
- Intraoperative fluorescence molecular imaging accelerates the coming of precision surgery in China.European journal of nuclear medicine and molecular imaging · 2022Review
- Chemotherapeutic nanomaterials in tumor boundary delineation: Prospects for effective tumor treatment.Acta pharmaceutica Sinica. B · 2022Review
- Fluorescence Image-Guided Navigation Surgery Using Indocyanine Green for Hepatoblastoma.Children (Basel, Switzerland) · 2021Review
- Explainable liver tumor delineation in surgical specimens using hyperspectral imaging and deep learning.Biomedical optics express · 2021Article
- Tumor visualization and fluorescence angiography with indocyanine green (ICG) in laparoscopic and robotic hepatobiliary surgery - valuation of early adopters from Germany.Innovative surgical sciences · 2021Article
- Article
- Novel method of intraoperative liver tumour localisation with indocyanine green and near-infrared imaging.Singapore medical journal · 2021Article
- A narrative review of near-infrared fluorescence imaging in hepatectomy for hepatocellular carcinoma.Annals of translational medicine · 2021Review
- Recent Advances in Second Near-Infrared Region (NIR-II) Fluorophores and Biomedical Applications.Frontiers in chemistry · 2021Review
- The application of laparoscopy combined with indocyanine green fluorescence imaging technique for hepatic cystic echinococcosis.BMC surgery · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeClear delineation between tumors and normal tissues is ideal for real-time surgical navigation imaging. We investigated applying indocyanine green (ICG) fluorescence imaging navigation using an intraoperative administration method in liver resection.
methodsFifty patients who underwent liver resection were divided into two groups based on clinical situation and operative purpose. In group I, sizes of superficial liver tumors were determined; tiny tumors were identified. In group II, the liver resection margin was determined; real-time navigation was performed. ICG was injected intravenously at the beginning of the operation; the liver surface was observed with a photodynamic eye (PDE).
resultsLiver resection margins were determined using PDE. Fluorescence contrast between normal liver and tumor tissues was obvious in 32 of 35 patients. A boundary for half the liver or specific liver segments was determined in nine patients by examining the portal vein anatomy after ICG injection. Eight small tumors not observed preoperatively were detected; the smallest was 2 mm.
conclusionsICG fluorescence imaging navigation is a promising, simple, and safe tool for routine real-time intraoperative imaging during hepatic resection and clinical exploration in hepatocellular carcinoma, enabling high sensibility for identifying liver resection margins and detecting tiny superficial tumors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.