Evidence map›Paper›PMID 27629787›Full record

ArticleMolecular and cellular biochemistry2016

Vascular endothelial over-expression of soluble epoxide hydrolase (Tie2-sEH) enhances adenosine A

Vishal R Yadav, Ka L Hong, Darryl C Zeldin, Mohammed A Nayeem

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular biochemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Adenosine AMolecular and cellular biochemistry · 2021
    Article
  4. Article
  5. Frontiers in pharmacology · 2020
    Article
  6. Article
  7. Enhanced AEuropean journal of pharmacology · 2019
    Article
  8. Article
  9. Role of oxylipins in cardiovascular diseases.Acta pharmacologica Sinica · 2018
    Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Vishal R YadavDepartment of Physiology and Pharmacology, College of Medicine, West Virginia University, Morgantown, WV, USA.
Ka L HongDepartment of Pharmaceutical Sciences, Center for Basic and Translational Stroke Research, Health Science Center-North, School of Pharmacy, West Virginia University, Biomedical Research Building, 2nd floor, Room # 220, 1 Medical Center Drive, PO Box 9530, Morgantown, WV, 26506-9530, USA.
Darryl C ZeldinDivision of Intramural Research, NIEHS/NIH, Research Triangle Park, NC, USA.
Mohammed A NayeemDepartment of Pharmaceutical Sciences, Center for Basic and Translational Stroke Research, Health Science Center-North, School of Pharmacy, West Virginia University, Biomedical Research Building, 2nd floor, Room # 220, 1 Medical Center Drive, PO Box 9530, Morgantown, WV, 26506-9530, USA. mnayeem@hsc.wvu.edu.
West Virginia University · USNational Institute of Environmental Health Sciences · US

Funding

Characterization And Functional Significance Of P450 Arachidonate EpoxygenasesZIAES025034 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ZELDIN, DARRYL C · 2009 to 2025
$18.6M
P450 Arachidonate EpoxygenasesZ01ES025034 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ZELDIN, DARRYL C · 1995 to 2008
$2.2M
Role of Cyp2j-epoxygenases, sEH and PPARs in adenosine-induced vascular responseR01HL114559 · NHLBI · WEST VIRGINIA UNIVERSITY · PI NAYEEM, MOHAMMED A · 2013 to 2017
$1.5M
Intramural NIH HHS Z01 ES025034NHLBI NIH HHS R01 HL114559
6 · The paper itself

Abstract

Soluble epoxide hydrolase (sEH) converts epoxyeicosatrienoic acids that are endothelium-derived hyperpolarizing factors into less active dihydroxyeicosatrienoic acids. Previously, we reported a decrease in adenosine A

Indexed as

VasoconstrictionAdenosine A1 Receptor AgonistsAnimalsCytochrome P-450 CYP4AEndothelial CellsEnzyme InhibitorsEpoxide HydrolasesKATP ChannelsMesenteric ArteriesMiceMice, TransgenicMitogen-Activated Protein Kinase 3Protein Kinase C-alphaReceptor, Adenosine A1Receptor, TIE-2Adenosine A1 Receptor AgonistsCytochrome P-450 CYP4AEnzyme InhibitorsEphx2 protein, mouseEpoxide HydrolasesKATP ChannelsMitogen-Activated Protein Kinase 3Prkca protein, mouseProtein Kinase C-alphaReceptor, Adenosine A1Receptor, TIE-2Tek protein, mouseA1ARContractionKATP channelMesenteric arteryRelaxationsEH

Identifiers

PMID27629787
PMCPMC5056159
OpenAlexW2520988517

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.