Evidence map›Paper›PMID 27629781›Full record

ArticleEuropean journal of pediatrics2016

Eosinophilic tubulointerstitial nephritis on treatment with isotretinoin.

Gulsah Kaya Aksoy, Mustafa Koyun, Bahar Akkaya, Elif Comak, Atilla Gemici, Sema Akman

Abstract readCase Reports
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In one paragraph

Article in European journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Isotretinoin and the Kidney: Opportunities and Threats.Clinical, cosmetic and investigational dermatology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Gulsah Kaya AksoyDepartment of Pediatric Nephrology, Akdeniz University, School of Medicine, Antalya, Turkey. gkayaaksoy@gmail.com.
Mustafa KoyunDepartment of Pediatric Nephrology, Akdeniz University, School of Medicine, Antalya, Turkey.
Bahar AkkayaDepartment of Pathology, Akdeniz University, School of Medicine, Antalya, Turkey.
Elif ComakDepartment of Pediatric Nephrology, Akdeniz University, School of Medicine, Antalya, Turkey.
Atilla GemiciDepartment of Pediatric Nephrology, Akdeniz University, School of Medicine, Antalya, Turkey.
Sema AkmanDepartment of Pediatric Nephrology, Akdeniz University, School of Medicine, Antalya, Turkey.
Akdeniz University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug-related acute tubulointerstitial nephritis is one of the most common causes of childhood acute renal failures which originate from kidneys. Sixteen-year old male patient with the history of isotretinoin use for the last 3 months was admitted with acute renal failure. Renal function parameters were measured as follows: blood urea nitrogen 21 mg/dL, serum creatinine 1.68 mg/dL, cystatin C 1.15 mg/L, and estimated glomerular filtration rate based on cystatin C 56.5 mL/min/1.73 m2. The patient whom pathological signs of renal biopsy sections revealed interstitial mononuclear cell and eosinophilic infiltration was diagnosed with acute tubulointerstitial nephritis.

conclusionIsotretinoin is a vitamin A-derived agent which is commonly used in the treatment of acne and may cause drug-related acute tubulointerstitial nephritis. What is Known: •Drug-related acute tubulointerstitial nephritis (ATIN) is one of the most common causes of childhood acute renal failures. What is New: •Isotretinoin may cause drug-related acute tubulointerstitial nephritis.

Indexed as

Acne VulgarisAcute Kidney InjuryAdolescentAnti-Inflammatory AgentsDermatologic AgentsHumansIsotretinoinKidneyMaleNephritis, InterstitialPrednisoloneAnti-Inflammatory AgentsDermatologic AgentsIsotretinoinPrednisoloneAcute tubulointerstitial nephritisDrug-related tubulointerstitial nephritisIsotretinoinRenal failure

Identifiers

PMID27629781
OpenAlexW2519524317

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.