ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016
Prefrontal Cortex Networks Shift from External to Internal Modes during Learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Categorization is 'baked' into the brain.Nature reviews. Neuroscience · 2026Review
- Network-nodal tACS induces right-lateralization of thalamocortical connectivity.Scientific reports · 2026Article
- Enhanced Hippocampus-Nidopallium Caudolaterale Interaction in Visual-Spatial Associative Learning of Pigeons.Animals : an open access journal from MDPI · 2024Article
- Attentional switch to memory: An early and critical phase of the cognitive cascade allowing autobiographical memory retrieval.Psychonomic bulletin & review · 2023Review
- Losses resulting from deliberate exploration trigger beta oscillations in frontal cortex.Frontiers in neuroscience · 2023Article
- Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human.Nature communications · 2022Article
- Concurrent neuroimaging and neurostimulation reveals a causal role for dlPFC in coding of task-relevant information.Communications biology · 2021Article
- Frontal eye field neurons selectively signal the reward value of prior actions.Progress in neurobiology · 2020Article
- Prefrontal oscillations modulate the propagation of neuronal activity required for working memory.Neurobiology of learning and memory · 2020Article
- TORUS GRAPHS FOR MULTIVARIATE PHASE COUPLING ANALYSIS.The annals of applied statistics · 2020Article
- Differential Roles of Mediodorsal Nucleus of the Thalamus and Prefrontal Cortex in Decision-Making and State Representation in a Cognitive Control Task Measuring Deficits in Schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Emergence of β and γ networks following multisensory training.NeuroImage · 2020Article
- Working Memory 2.0.Neuron · 2018Review
- Detecting multivariate cross-correlation between brain regions.Journal of neurophysiology · 2018Article
- Alpha desynchronization/synchronization during working memory testing is compromised in acute mild traumatic brain injury (mTBI).PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
unlabelledAs we learn about items in our environment, their neural representations become increasingly enriched with our acquired knowledge. But there is little understanding of how network dynamics and neural processing related to external information changes as it becomes laden with "internal" memories. We sampled spiking and local field potential activity simultaneously from multiple sites in the lateral prefrontal cortex (PFC) and the hippocampus (HPC)-regions critical for sensory associations-of monkeys performing an object paired-associate learning task. We found that in the PFC, evoked potentials to, and neural information about, external sensory stimulation decreased while induced beta-band (∼11-27 Hz) oscillatory power and synchrony associated with "top-down" or internal processing increased. By contrast, the HPC showed little evidence of learning-related changes in either spiking activity or network dynamics. The results suggest that during associative learning, PFC networks shift their resources from external to internal processing. SIGNIFICANCE STATEMENT: As we learn about items in our environment, their representations in our brain become increasingly enriched with our acquired "top-down" knowledge. We found that in the prefrontal cortex, but not the hippocampus, processing of external sensory inputs decreased while internal network dynamics related to top-down processing increased. The results suggest that during learning, prefrontal cortex networks shift their resources from external (sensory) to internal (memory) processing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.