Evidence map›Paper›PMID 27629590›Full record

ReviewJournal of computational neuroscience2017

Twenty years of ModelDB and beyond: building essential modeling tools for the future of neuroscience.

Robert A McDougal, Thomas M Morse, Ted Carnevale, Luis Marenco, Rixin Wang, Michele Migliore, Perry L Miller, Gordon M Shepherd, Michael L Hines

Abstract readReview
In one paragraph

Review in Journal of computational neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Shaping the Action Potential in Dorsal Root and Trigeminal Ganglia Neurons: Relevance to Pain Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Hippocampome.org, a resource for subicular neuron types and beyond.bioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. WhenAPL bioengineering · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Building on models-a perspective for computational neuroscience.Cerebral cortex (New York, N.Y. : 1991) · 2025
    Article
  20. Article

78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Robert A McDougalDepartment of Neuroscience, Yale University, PO Box 208001, New Haven, CT, 06520-8001, USA. robert.mcdougal@yale.edu.
Thomas M MorseDepartment of Neuroscience, Yale University, PO Box 208001, New Haven, CT, 06520-8001, USA.
Ted CarnevaleDepartment of Neuroscience, Yale University, PO Box 208001, New Haven, CT, 06520-8001, USA.
Luis MarencoDepartment of Neuroscience, Yale University, PO Box 208001, New Haven, CT, 06520-8001, USA.
Rixin WangCenter for Medical Informatics, Yale University, New Haven, CT, 06520, USA.
Michele MiglioreDepartment of Neuroscience, Yale University, PO Box 208001, New Haven, CT, 06520-8001, USA.
Perry L MillerVA Connecticut Healthcare System, West Haven, CT, 06516, USA.
Gordon M ShepherdDepartment of Neuroscience, Yale University, PO Box 208001, New Haven, CT, 06520-8001, USA.
Michael L HinesDepartment of Neuroscience, Yale University, PO Box 208001, New Haven, CT, 06520-8001, USA.

Funding

MEDICAL INFORMATICS RESEARCH TRAINING AT YALET15LM007056 · NLM · YALE UNIVERSITY · PI Mark Bender Gerstein, LUCILA OHNO-MACHADO · 1987 to 2026
$22.2M
SenseLab: Integration of Multidisciplinary Sensory DataR01DC009977 · NIDCD · YALE UNIVERSITY · PI HINES, MICHAEL L, MCDOUGAL, ROBERT A. · 2009 to 2018
$6.7M
YALE BIOMEDICAL SUPERCOMPUTER: NEUROSCIENCES10RR019895 · NCRR · YALE UNIVERSITY · PI WILLIAMS, KENNETH ROBERT · 2004 to 2004
$1.6M
High Performance Computing Instrumentation for Yale University Biomedical HPC CenS10RR029676 · NCRR · YALE UNIVERSITY · PI BJORNSON, ROBERT DEAN · 2011 to 2011
$588k
NCRR NIH HHS S10 RR019895NCRR NIH HHS S10 RR029676NIDCD NIH HHS R01 DC009977NLM NIH HHS T15 LM007056
6 · The paper itself

Abstract

Neuron modeling may be said to have originated with the Hodgkin and Huxley action potential model in 1952 and Rall's models of integrative activity of dendrites in 1964. Over the ensuing decades, these approaches have led to a massive development of increasingly accurate and complex data-based models of neurons and neuronal circuits. ModelDB was founded in 1996 to support this new field and enhance the scientific credibility and utility of computational neuroscience models by providing a convenient venue for sharing them. It has grown to include over 1100 published models covering more than 130 research topics. It is actively curated and developed to help researchers discover and understand models of interest. ModelDB also provides mechanisms to assist running models both locally and remotely, and has a graphical tool that enables users to explore the anatomical and biophysical properties that are represented in a model. Each of its capabilities is undergoing continued refinement and improvement in response to user experience. Large research groups (Allen Brain Institute, EU Human Brain Project, etc.) are emerging that collect data across multiple scales and integrate that data into many complex models, presenting new challenges of scale. We end by predicting a future for neuroscience increasingly fueled by new technology and high performance computation, and increasingly in need of comprehensive user-friendly databases such as ModelDB to provide the means to integrate the data for deeper insights into brain function in health and disease.

Indexed as

Databases, FactualModels, NeurologicalNeurosciencesBrainHumansNeuronsModel analysisModel discoveryModel sharingNeuroinformaticsReproducibility

Identifiers

PMID27629590
PMCPMC5279891

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.