ArticleBMC microbiology2016
Whole genome sequencing of Salmonella Typhimurium illuminates distinct outbreaks caused by an endemic multi-locus variable number tandem repeat analysis type in Australia, 2014.
Article in BMC microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Article
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- DODGE: automated point source bacterial outbreak detection using cumulative long term genomic surveillance.Bioinformatics (Oxford, England) · 2024Article
- Evidence of international transmission of mobile colistin resistant monophasic Salmonella Typhimurium ST34.Scientific reports · 2023Article
- Optimization and Validation of Candida auris Short Tandem Repeat Analysis.Microbiology spectrum · 2022Article
- Evaluation of Antibiotic Resistance ofAntibiotics (Basel, Switzerland) · 2021Article
- Enhancing genomics-based outbreak detection of endemicMicrobial genomics · 2021Article
- Genomic Characterization ofPathogens (Basel, Switzerland) · 2021Article
- Toward an Integrated Genome-Based Surveillance ofFrontiers in microbiology · 2021Article
- Nonsynonymous Polymorphism Counts in Bacterial Genomes: a Comparative Examination.Applied and environmental microbiology · 2020Article
- Combining Whole-Genome Sequencing and Multimodel Phenotyping To Identify Genetic Predictors ofmSphere · 2020Article
- Phylogenetic analysis revealed that Salmonella Typhimurium ST313 isolated from humans and food in Brazil presented a high genomic similarity.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Clinically Unreported Salmonellosis Outbreak Detected via Comparative Genomic Analysis of Municipal WastewaterApplied and environmental microbiology · 2019Article
- Childhood Diarrhoea in the Eastern Mediterranean Region with Special Emphasis on Non-Typhoidal Salmonella at the Human⁻Food Interface.Pathogens (Basel, Switzerland) · 2019Review
- A One Health investigation of Salmonella enterica serovar Wangata in north-eastern New South Wales, Australia, 2016-2017.Epidemiology and infection · 2019Article
- Diversity of Salmonella serotypes from humans, food, domestic animals and wildlife in New South Wales, Australia.BMC infectious diseases · 2018Article
- Article
- Bacterial genome sequencing in clinical microbiology: a pathogen-oriented review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Review
- Phenotypic and Genotypic Eligible Methods forFrontiers in microbiology · 2017Review
- Retrospective use of whole genome sequencing to better understand an outbreak ofWestern Pacific surveillance and response journal : WPSARArticle
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSalmonella Typhimurium (STM) is an important cause of foodborne outbreaks worldwide. Subtyping of STM remains critical to outbreak investigation, yet current techniques (e.g. multilocus variable number tandem repeat analysis, MLVA) may provide insufficient discrimination. Whole genome sequencing (WGS) offers potentially greater discriminatory power to support infectious disease surveillance.
methodsWe performed WGS on 62 STM isolates of a single, endemic MLVA type associated with two epidemiologically independent, food-borne outbreaks along with sporadic cases in New South Wales, Australia, during 2014. Genomes of case and environmental isolates were sequenced using HiSeq (Illumina) and the genetic distance between them was assessed by single nucleotide polymorphism (SNP) analysis. SNP analysis was compared to the epidemiological context.
resultsThe WGS analysis supported epidemiological evidence and genomes of within-outbreak isolates were nearly identical. Sporadic cases differed from outbreak cases by a small number of SNPs, although their close relationship to outbreak cases may represent an unidentified common food source that may warrant further public health follow up. Previously unrecognised mini-clusters were detected.
conclusionsWGS of STM can discriminate foodborne community outbreaks within a single endemic MLVA clone. Our findings support the translation of WGS into public health laboratory surveillance of salmonellosis.
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