ArticleScientific reports2016
Amyloid structure exhibits polymorphism on multiple length scales in human brain tissue.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 60 citations in OpenAlex.
- Scanning X-ray microdiffraction studies of protein accumulation and tissue loss in thin sections of human brain tissue in Alzheimer's disease.Research square · 2026Article
- Whole-mount diffracted X-ray blinking analysis of intracellular amyloid-β-associated nanoscale dynamics inBiology methods & protocols · 2026Article
- Molecular polymorphism of tau aggregates in Pick's disease.Neurobiology of disease · 2025Article
- Structural diversity of Alzheimer-related protein aggregations revealed using photothermal ratio-metric micro-spectroscopy.Biomedical optics express · 2024Article
- Characterization of sub-micrometre-sized voids in fixed human brain tissue using scanning X-ray microdiffraction.Journal of applied crystallography · 2024Article
- An electrostatic cluster guides Aβ40 fibril formation in sporadic and Dutch-type cerebral amyloid angiopathy.Journal of structural biology · 2024Article
- Identifying Biological and Biophysical Features of Different Maturation States of α-Synuclein Amyloid Fibrils.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Cross interactions between Apolipoprotein E and amyloid proteins in neurodegenerative diseases.Computational and structural biotechnology journal · 2023Review
- Time-Resolved In Situ AFM Measurement of Growth Rates of Aβ40 Fibrils.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Small-angle X-ray microdiffraction from fibrils embedded in tissue thin sections.Journal of applied crystallography · 2022Article
- A comparison of deep-learning-based inpainting techniques for experimental X-ray scattering.Journal of applied crystallography · 2022Article
- Scanning x-ray microdiffraction: In situ molecular imaging of tissue and materials.Current opinion in structural biology · 2022Review
- Mapping the Spatial Distribution of Fibrillar Polymorphs in Human Brain Tissue.Frontiers in neuroscience · 2022Article
- Distinct conformers of amyloid beta accumulate in the neocortex of patients with rapidly progressive Alzheimer's disease.The Journal of biological chemistry · 2021Article
- The existence of Aβ strains and their potential for driving phenotypic heterogeneity in Alzheimer's disease.Acta neuropathologica · 2021Review
- Nanostructure-specific X-ray tomography reveals myelin levels, integrity and axon orientations in mouse and human nervous tissue.Nature communications · 2021Article
- Amyloid Structural Changes Studied by Infrared Microspectroscopy in Bigenic Cellular Models of Alzheimer's Disease.International journal of molecular sciences · 2021Article
- Label-free X-ray estimation of brain amyloid burden.Scientific reports · 2020Article
- Older, non-demented apolipoprotein εNeurobiology of aging · 2020Article
- The Structural Basis of Amyloid Strains in Alzheimer's Disease.ACS biomaterials science & engineering · 2020Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Aggregation of Aβ amyloid fibrils into plaques in the brain is a universal hallmark of Alzheimer's Disease (AD), but whether plaques in different individuals are equivalent is unknown. One possibility is that amyloid fibrils exhibit different structures and different structures may contribute differentially to disease, either within an individual brain or between individuals. However, the occurrence and distribution of structural polymorphisms of amyloid in human brain is poorly documented. Here we use X-ray microdiffraction of histological sections of human tissue to map the abundance, orientation and structural heterogeneities of amyloid. Our observations indicate that (i) tissue derived from subjects with different clinical histories may contain different ensembles of fibrillar structures; (ii) plaques harboring distinct amyloid structures can coexist within a single tissue section and (iii) within individual plaques there is a gradient of fibrillar structure from core to margins. These observations have immediate implications for existing theories on the inception and progression of AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.