ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017
Genome-Wide Association Study of Loneliness Demonstrates a Role for Common Variation.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genetics of OCD and Related Disorders; Searching for Shared Factors.Current topics in behavioral neurosciences · 2021Pooled it
- Genome-wide association study of shared liability to anxiety disorders in Army STARRS.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2020Pooled it
- Developmental trajectories and dynamic associations between loneliness and non-suicidal self-injury in adolescents: the longitudinal mediating role of mobile phone dependence.Child and adolescent psychiatry and mental health · 2026Article
- Shared genetic architecture between autism spectrum disorder, loneliness, and social isolation reveals novel genetic loci.Psychiatric genetics · 2026Article
- Optimization of potential targets for antidepressant Chinese medicines: AI and multi-omics methods.Chinese medicine · 2026Review
- The effects of nicotine exposure on depression: An integrative analysis combining network toxicology, molecular docking, and Mendelian randomization.Tobacco induced diseases · 2026Article
- All the Lonely People: An Integrated Review and Research Agenda on Work and Loneliness.Journal of management · 2026Review
- Unraveling the Shared Genetic Architecture and Polygenic Overlap Between Loneliness, Major Depressive Disorder, and Sleep-Related Traits.Biomedicines · 2025Article
- Decomposing genetic effects of social connectedness and depression on youth behaviors and long-term clinical outcomes.medRxiv : the preprint server for health sciences · 2025Article
- Neurobiological correlates of schizophrenia-specific and highly pleiotropic genetic risk scores for neuropsychiatric disorders.Translational psychiatry · 2025Article
- Epigenome-wide association study of loneliness in a sample of U.S. middle-aged twins.Epigenetics · 2024Article
- Complete Loss of Natural Teeth and Loneliness: A Fixed-Effect Analysis.Journal of dental research · 2024Article
- A Genetically Informed Study of the Association Between Perceived Stress and Loneliness.Behavior genetics · 2024Article
- Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies.Molecular psychiatry · 2023Review
- Understanding the relationship between loneliness, substance use traits and psychiatric disorders: A genetically informed approach.Psychiatry research · 2023Article
- Identifying novel proteins underlying loneliness by integrating GWAS summary data with human brain proteomes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Frailty trajectory predicts subsequent cognitive decline: A 26-year population-based longitudinal cohort study.MedComm · 2023Article
- Neurogenetics and Epigenetics of Loneliness.Psychology research and behavior management · 2023Review
- Loneliness, Depression, and Genetics in the Elderly: Prognostic Factors of a Worse Health Condition?International journal of environmental research and public health · 2022Article
- What next for eating disorder genetics? Replacing myths with facts to sharpen our understanding.Molecular psychiatry · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Loneliness is a complex biological trait that has been associated with numerous negative health outcomes. The measurement and environmental determinants of loneliness are well understood, but its genetic basis is not. Previous studies have estimated the heritability of loneliness between 37 and 55% using twins and family-based approaches, and have explored the role of specific candidate genes. We used genotypic and phenotypic data from 10 760 individuals aged ⩾50 years that were collected by the Health and Retirement Study (HRS) to perform the first genome-wide association study of loneliness. No associations reached genome-wide significance (p>5 × 10
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.