ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017
Pathogen-Host Defense in the Evolution of Depression: Insights into Epidemiology, Genetics, Bioregional Differences and Female Preponderance.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Impact of parasitic infection on mental health and illness in humans in Africa: a systematic review.Parasitology · 2022Pooled it
- Effects of Oats (Frontiers in nutrition · 2021Pooled it
- Pro-inflammatory Monocyte Phenotype and Cell-Specific Steroid Signaling Alterations in Unmedicated Patients With Major Depressive Disorder.Frontiers in immunology · 2018Trial
- Associations between inflammation markers (CRP and IL-6) and depression among adolescents and young adults in Soweto and Durban, South Africa.Brain, behavior, & immunity - health · 2026Article
- Preexisting Depression or Anxiety is Associated with Increased Wound Complications Following Breast Reduction Surgery: A Real-World Cohort Study.Aesthetic plastic surgery · 2026Article
- Women's mental health: current status and evolutionary perspectives.Evolutionary human sciences · 2026Review
- Insomnia and Inflammation Conspire to Heighten Depression Risk: Implications for Treatment and Prevention of Mood Disorders.Biological psychiatry · 2025Review
- Glucosinolate Metabolites and Brain Health: An Updated Review on Their Potential Benefits in Neurodegenerative, Neurodevelopmental, and Psychiatric Disorders.Antioxidants (Basel, Switzerland) · 2025Review
- Role of inflammation in depressive and anxiety disorders, affect, and cognition: genetic and non-genetic findings in the lifelines cohort study.Translational psychiatry · 2025Article
- Exploring the role of neuronal-enriched extracellular vesicle miR-93 and interoception in major depressive disorder.Translational psychiatry · 2024Article
- Physical activity, low-grade inflammation, and psychological responses to the COVID-19 pandemic among older adults in England.medRxiv : the preprint server for health sciences · 2024Article
- Review
- Imipramine Administration inPharmaceuticals (Basel, Switzerland) · 2023Article
- Examining the Relationships between the Incidence of Infectious Diseases and Mood Disorders: An Analysis of Data from the Global Burden of Disease Studies, 1990-2019.Diseases (Basel, Switzerland) · 2023Article
- Toll-like receptor 3 neuroimmune signaling and behavior change: A strain comparison between Lewis and Wistar rats.Behavioural brain research · 2023Article
- Injury, illness, and emotion: A review of the motivational continuum from trauma through recovery from an ecological perspective.Brain, behavior, & immunity - health · 2023Review
- Inflammation, amygdala-ventromedial prefrontal functional connectivity and symptoms of anxiety and PTSD in African American women recruited from an inner-city hospital: Preliminary results.Brain, behavior, and immunity · 2022Article
- Increased Prevalence of Depressive Symptoms in Patients Undergoing Revision for Periprosthetic Joint Infection.Arthroplasty today · 2022Article
- Gender differences in major depressive disorders: A resting state fMRI study.Frontiers in psychiatry · 2022Article
- IFP35 Is a Relevant Factor in Innate Immunity, Multiple Sclerosis, and Other Chronic Inflammatory Diseases: A Review.Biology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Significant attention has been paid to the potential adaptive value of depression as it relates to interactions with people in the social world. However, in this review, we outline the rationale of why certain features of depression including its environmental and genetic risk factors, its association with the acute phase response and its age of onset and female preponderance appear to have evolved from human interactions with pathogens in the microbial world. Approaching the relationship between inflammation and depression from this evolutionary perspective yields a number of insights that may reveal important clues regarding the origin and epidemiology of the disorder as well as the persistence of its risk alleles in the modern human genome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.