ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017
Psychoneuroimmunology of Early-Life Stress: The Hidden Wounds of Childhood Trauma?
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 193 papers, 4 of them syntheses that pooled it.
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Who cites it
193 citing papers in PubMed, 4 syntheses or guidelines pooled it, 371 citations in OpenAlex.
- Multi-epigenome-wide analyses and meta-analysis of child maltreatment in judicial autopsies and intervened children and adolescents.Molecular psychiatry · 2026Pooled it
- Global research landscape, knowledge structure, and emerging trends in adverse childhood experiences and personality disorders: a bibliometric analysis.Frontiers in psychiatry · 2026Pooled it
- A Systematic Review of Opioid Use Disorder and Related Biomarkers.Frontiers in psychiatry · 2021Pooled it
- Peripheral complement proteins in schizophrenia: A systematic review and meta-analysis of serological studies.Schizophrenia research · 2020Pooled it
- The influence of identity-oriented psychotrauma therapy on Hashimoto disease activity: a randomised controlled trial.European journal of psychotraumatology · 2025Trial
- Childhood Adversities and the ATTACHInternational journal of environmental research and public health · 2024Trial
- The Consequences of Foster Care Versus Institutional Care in Early Childhood on Adolescent Cardiometabolic and Immune Markers: Results From a Randomized Controlled Trial.Psychosomatic medicine · 2019Trial
- The effect of beta-adrenergic blockade on inflammatory and cardiovascular responses to acute mental stress.Brain, behavior, and immunity · 2018Trial
- Early attachment disruption differentially enhances multiple signs of microglia activation in the prefrontal cortex, hippocampus, and preoptic area of periadolescent guinea pigs.Behavioural brain research · 2027Article
- Childhood peer abuse moderates associations of inflammation and cortisol with subcortical brain volume.European journal of psychotraumatology · 2026Article
- Identifying differential interactions of potentially traumatic experiences with genetic risk for posttraumatic stress disorder.European journal of psychotraumatology · 2026Article
- Pro-inflammatory markers interact with spontaneous theta oscillations to predict depression among adolescents.Brain, behavior, and immunity · 2026Article
- Targeting Nav1.6: a promising strategy against cognitive impairment in maternal separation-sensitive mice.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026Article
- Neuroinflammation and depression: immune-brain interface mechanisms, biomarker stratification, and therapeutic strategies.Translational psychiatry · 2026Review
- Adverse childhood experiences (ACEs) moderate the association between traffic exposure and circulating inflammatory biomarkers.Brain, behavior, & immunity - health · 2026Article
- Long-term molecular embedding of early life adversity: leukocyte DNA methylation and gene expression associations from childhood to young adulthood.Epigenomics · 2026Article
- Adverse Childhood Experiences and Growth Outcomes in Childhood: A Longitudinal EHR-Based Study.medRxiv : the preprint server for health sciences · 2026Article
- Development and validation of the lifetime sense of safety scale in Kenyan adults.Communications medicine · 2026Article
- Age-related moderation of adjunctive psychotherapy and early life stress effects on depression symptom reductions following ketamine treatment: Initial insights from a large, naturalistic sample.Journal of affective disorders · 2026Article
- The role of proinflammatory response and the kynurenine pathway in the association between childhood maltreatment and lifetime substance use disorder.Neurobiology of stress · 2026Article
133 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain and the immune system are not fully formed at birth, but rather continue to mature in response to the postnatal environment. The two-way interaction between the brain and the immune system makes it possible for childhood psychosocial stressors to affect immune system development, which in turn can affect brain development and its long-term functioning. Drawing from experimental animal models and observational human studies, we propose that the psychoneuroimmunology of early-life stress can offer an innovative framework to understand and treat psychopathology linked to childhood trauma. Early-life stress predicts later inflammation, and there are striking analogies between the neurobiological correlates of early-life stress and of inflammation. Furthermore, there are overlapping trans-diagnostic patterns of association of childhood trauma and inflammation with clinical outcomes. These findings suggest new strategies to remediate the effect of childhood trauma before the onset of clinical symptoms, such as anti-inflammatory interventions and potentiation of adaptive immunity. Similar strategies might be used to ameliorate the unfavorable treatment response described in psychiatric patients with a history of childhood trauma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.