Evidence map›Paper›PMID 27629273›Full record

Trial reportEarly intervention in psychiatry2018

Examining the durability of a hybrid, remote and computer-based cognitive remediation intervention for adolescents with 22q11.2 deletion syndrome.

Margaret A Mariano, Kerri Tang, Matthew Kurtz, Wendy R Kates

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Early intervention in psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00917189 (Computer-Based Cognitive Remediation in Adolescents With VCFS), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00917189 nacompletednot on this map

Computer-Based Cognitive Remediation in Adolescents With VCFS

TypeinterventionalSponsorState University of New York - Upstate Medical UniversityRan2009 to 2015Enrolled37ConditionsVelocardiofacial SyndromeArmsChallenging Our Minds Program
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. ω-3PUFAs Improve Cognitive Impairments Through Ser133 Phosphorylation of CREB Upregulating BDNF/TrkB Signal in Schizophrenia.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Article
  3. Childhood Executive Functioning Predicts Young Adult Outcomes in 22q11.2 Deletion Syndrome.Journal of the International Neuropsychological Society : JINS · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Margaret A MarianoDepartment of Psychiatry and Behavioral Sciences, State University of New York at Upstate Medical University, Syracuse, New York, USA.
Kerri TangDepartment of Psychiatry and Behavioral Sciences, State University of New York at Upstate Medical University, Syracuse, New York, USA.
Matthew KurtzDepartment of Psychology, Wesleyan University, Middletown, Connecticut, USA.
Wendy R KatesDepartment of Psychiatry and Behavioral Sciences, State University of New York at Upstate Medical University, Syracuse, New York, USA.
SUNY Upstate Medical University · USWesleyan University · US

Funding

Computer-Based Cognitive Remediation in Adolescents with VCFSR33MH085901 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI KATES, WENDY · 2011 to 2013
$681k
Computer-Based Cognitive Remediation in Adolescents with VCFSR21MH085901 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI KATES, WENDY · 2009 to 2010
$445k
NIMH NIH HHS R21 MH085901NIMH NIH HHS R33 MH085901
6 · The paper itself

Abstract

aimSchizophrenia and 22q11.2 deletion syndrome (22q11DS) share similar patterns of cognitive deficits. Up to 30% of those with 22q11DS develop schizophrenia during early adulthood. As cognitive decline has recently been found to predict onset of psychosis in adolescents with 22q11DS, early interventions such as cognitive remediation (CR) during adolescence are warranted. This paper investigates the durability of a remote, computerized, CR programme for youth with 22q11DS. Our aim was to determine if the positive effects of CR persisted 6 months beyond intervention completion.

methodsA longitudinal design with 21 participants serving as their own controls was used. Youth were seen for neurocognitive assessments at pre-treatment, after the targeted 8-month intervention, at post-treatment, and 6 months after for follow-up. During the intervention, cognitive coaches met remotely with participants for CR via video conferencing three times a week, and offered task-specific strategies. To determine if intervention improvements held across the 6-month follow-up period, neurocognitive measures were statistically examined with repeated measures analysis of variances from pre-treatment through follow-up.

resultsOur CR intervention proved durable. Post-treatment improvements comprising cognitive flexibility, executive function, reaction time and working memory were maintained over the follow-up period.

conclusionsResults confirm previous research regarding the durability of CR treatment and extend these findings to youth with 22q11DS. The present study may serve to inform early intervention efforts focused on cognitive and functionally relevant rehabilitation goals for youth with 22q11DS and suggests that 22q11DS can potentially serve as a suitable model for examining the trajectory preceding psychosis.

Indexed as

CognitionAdolescentCognitive RemediationDiGeorge SyndromeFemaleHumansMaleTherapy, Computer-AssistedVideoconferencing22q11.2 deletion syndromeadolescentscognitive remediationearly intervention in psychosisfollow-up study

Identifiers

PMID27629273
PMCPMC5352536
OpenAlexW2522013393

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.