ArticleJournal of atherosclerosis and thrombosis2017
Potential Role of Lipometabolism-Related MicroRNAs in Peripheral Blood Mononuclear Cells as Biomarkers for Coronary Artery Disease.
Article in Journal of atherosclerosis and thrombosis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Diagnostic Accuracy of Circulating MicroRNAs for Coronary Artery Disease: An Updated Systematic Review and Meta-analysis.Journal of cardiovascular translational research · 2026Pooled it
- Circulating microRNAs as biomarkers for ischemic heart disease: a systematic review and gene set enrichment analysis.Frontiers in medicine · 2025Pooled it
- The diagnostic value of circulating microRNAs as biomarkers for coronary artery disease: A meta‑analysis.Anatolian journal of cardiology · 2020Pooled it
- PBMCs to Stress-Associated miR-18a-5p and miR-22-3p Ratios as New Indicators of Metabolic Syndrome.BioMed research international · 2020Trial
- Role of miR-128-3p and miR-195-5p as biomarkers of coronary artery disease in Indians: a pilot study.Scientific reports · 2024Article
- Pharmacogenomics-based systematic review of coronary artery disease based on personalized medicine procedure.Heliyon · 2024Article
- MicroRNAs as Biomarkers for Coronary Artery Disease Related to Type 2 Diabetes Mellitus-From Pathogenesis to Potential Clinical Application.International journal of molecular sciences · 2022Review
- Article
- Genomic Variants and Multilevel Regulation ofJournal of cardiovascular development and disease · 2021Review
- Comprehensive Analysis of ceRNA Regulation Network Involved in the Development of Coronary Artery Disease.BioMed research international · 2021Article
- Circulating microRNA as a Biomarker for Coronary Artery Disease.Biomolecules · 2020Review
- A novel plasma lncRNA ENST00000416361 is upregulated in coronary artery disease and is related to inflammation and lipid metabolism.Molecular medicine reports · 2020Article
- Article
- Dysregulations of MicroRNA and Gene Expression in Chronic Venous Disease.Journal of clinical medicine · 2020Article
- Association between the transporters ABCA1/G1 and the expression of miR-33a/144 and the carotid intima media thickness in patients with arterial hypertension.Molecular biology reports · 2020Article
- miR-10a in Peripheral Blood Mononuclear Cells Is a Biomarker for Sepsis and Has Anti-Inflammatory Function.Mediators of inflammation · 2020Article
- Circulating microRNAs as possible biomarkers for coronary artery disease: a narrative review.EJIFCC · 2019Review
- MicroRNAs or Long Noncoding RNAs in Diagnosis and Prognosis of Coronary Artery Disease.Aging and disease · 2019Review
- Dysregulation of MicroRNA Regulatory Network in Lower Extremities Arterial Disease.Frontiers in genetics · 2019Article
- MiR-140-3p is Involved in In-Stent Restenosis by Targeting C-Myb and BCL-2 in Peripheral Artery Disease.Journal of atherosclerosis and thrombosis · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo explore the relationship between lipometabolism-related microRNAs (miRNAs) in peripheral blood mononuclear cells (PBMCs) and the presence of coronary artery disease (CAD).
methodsIn the present study, 161 stable CAD patients and 149 health controls were enrolled. The expression levels of seven miRNAs (miR-21, miR-24, miR-29a, miR-33a, miR-34a, miR-103a, and miR-122) in PBMCs were qualified by quantitative real-time polymerase chain reaction (qRT-PCR). The miRNA markers that showed significant difference between the two groups were used for further analysis. The risk of miRNA contributing to the presence of CAD was estimated by univariate and multivariate logistic regression models. The area under the receiver operating characteristic curve (AUC) was used to evaluate diagnostic accuracy.
resultsThe expression levels of miR-24, miR-33a, miR-103a, and miR-122 in PBMCs were significantly increased in CAD patients compared with controls and were significantly correlated with blood lipids in both CAD patients and controls. The increased levels of miR-24 (adjusted OR=1.32, 95% CI 1.07-1.62, P=0.009), miR-33a (adjusted OR=1.57, 95% CI 1.35-1.81, P＜0.001), miR-103a (adjusted OR=1.01, 95% CI 1.01-1.02, P＜0.001), and miR-122 (adjusted OR=1.03, 95% CI 1.01-1.04, P＜0.001) were associated with risk of CAD. We identified a miRNA panel (miR-24, miR-33, miR-103a, and miR-122) that provided a high diagnostic accuracy of CAD (AUC=0.911, 95% CI 0.880-0.942).
conclusionThe increased expression levels of miR-24, miR-33a, miR-103a, and miR-122 in PBMCs are associated with risk of CAD. A panel of the four miRNAs has considerable clinical value in diagnosing stable CAD.
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Registered trials
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