Evidence map›Paper›PMID 27629158›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2017

Altered intracortical myelin staining in the dorsolateral prefrontal cortex in severe mental illness.

Evelyn M R Lake, Eric A Steffler, Christopher D Rowley, Manpreet Sehmbi, Luciano Minuzzi, Benicio N Frey, Nicholas A Bock

Abstract read
PubMed Publisher
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
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  5. Investigating hierarchical critical periods in human neurodevelopment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  6. Cortical myelin mapping in antipsychotic medication-naïve, first-episode psychosis patients.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  7. Leveraging ultra-high field (7T) MRI in psychiatric research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  8. Article
  9. Article
  10. Intracortical Myelin in Youths at Risk for Depression.Biological psychiatry global open science · 2024
    Article
  11. From the Friend to the Foe-International journal of molecular sciences · 2024
    Review
  12. Review
  13. Article
  14. The Modulatory Effect ofNutrients · 2022
    Article
  15. Review
  16. Article
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  18. Article
  19. Article
  20. Reduced oligodendrocyte density in layer 5 of the prefrontal cortex in schizophrenia.European archives of psychiatry and clinical neuroscience · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Evelyn M R LakeImaging Research, Sunnybrook Research Institute, Toronto, ON, Canada.
Eric A StefflerDepartment of Psychology, Neuroscience and Behaviour, McMaster University, Psychology Complex, Room 304, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
Christopher D RowleyDepartment of Psychology, Neuroscience and Behaviour, McMaster University, Psychology Complex, Room 304, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
Manpreet SehmbiDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Luciano MinuzziDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Benicio N FreyDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Nicholas A BockDepartment of Psychology, Neuroscience and Behaviour, McMaster University, Psychology Complex, Room 304, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. bockn@mcmaster.ca.
McMaster University · CASunnybrook Health Science Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Imaging and postmortem studies into the severe mental illnesses of major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ) have revealed deficiencies in the myelination of deep white matter tracts of the brain. Recent studies have further suggested that deficits could extend to myelinated fibers running through the cortex in those illnesses. Disruptions in this intracortical myelin may underlie functional symptomology in MDD, BD, and SZ; thus, in this study, we hypothesized that individuals with these illnesses may have reduced myelin staining relative to controls in the cerebral cortex. We stained 60 sections of dorsolateral prefrontal cortex for myelin with Luxol

Indexed as

AdultAmidinesBipolar DisorderFemaleHumansMajor Depressive DisorderMaleMiddle AgedMyelin SheathNerve Fibers, MyelinatedPrefrontal CortexSchizophreniaAmidinesdiamidino compound 253-50Bipolar disorderCerebral cortexMajor depressive disorderMyelinSchizophrenia

Identifiers

PMID27629158
OpenAlexW2520118764

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.