ArticleAge (Dordrecht, Netherlands)2016
Age at menarche and age at natural menopause in East Asian women: a genome-wide association study.
Article in Age (Dordrecht, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 5 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Genome-wide association study of age at menarche in the Taiwan Biobank suggests NOL4 as a novel associated gene.Journal of human genetics · 2023Pooled it
- A Systematic Literature Review of Factors Affecting the Timing of Menarche: The Potential for Climate Change to Impact Women's Health.International journal of environmental research and public health · 2020Pooled it
- Association between serum uric acid levels and dyslipidemia in Chinese adults: A cross-sectional study and further meta-analysis.Medicine · 2020Pooled it
- Age at menarche and epithelial ovarian cancer risk: A meta-analysis and Mendelian randomization study.Cancer medicine · 2019Pooled it
- Pooled it
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- Holding Out for a Model: Rhomboid Superfamily in Vertebrate Development and Disease.Journal of cellular physiology · 2025Review
- Identification of loci associated with women's reproductive traits and exploration of a shared genetic basis with obesity.Human genomics · 2025Article
- The Association Between Serum Uric Acid Levels and the 10-Year Prospective Risk of Dyslipidemia: A Cohort Study From Healthy Heart Project (YHHP).Health science reports · 2025Article
- Genetic and non-genetic factors in prediction of early pubertal development in Chinese girls.Frontiers in endocrinology · 2024Article
- Chromosomal polymorphisms and susceptibility to menstrual disorders: a retrospective analysis of 24,578 women.Archives of gynecology and obstetrics · 2023Article
- Mechanisms of ovarian aging in women: a review.Journal of ovarian research · 2023Review
- Next-generation sequencing of 500 POI patients identified novel responsible monogenic and oligogenic variants.Journal of ovarian research · 2023Article
- Age at Natural Menopause and Influencing Factors in Women Attending the Gynecological Outpatient Clinic at a Tertiary Care Hospital.International journal of women's health · 2023Article
- Effects of age and sex on vasomotor activity and baroreflex sensitivity during the sleep-wake cycle.Scientific reports · 2022Article
- Age Cutoff for Early-Onset Parkinson's Disease: Recommendations from the International Parkinson and Movement Disorder Society Task Force on Early Onset Parkinson's Disease.Movement disorders clinical practice · 2022Review
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- Women's reproductive span: a systematic scoping review.Human reproduction open · 2022Article
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- Homozygous variants inJournal of medical genetics · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
19 authors at 6 institutions in 3 countries.
Funding
Abstract
Age at menarche (AM) and age at natural menopause (ANM) are complex traits with a high heritability. Abnormal timing of menarche or menopause is associated with a reduced span of fertility and risk for several age-related diseases including breast, endometrial and ovarian cancer, cardiovascular disease, and osteoporosis. To identify novel genetic loci for AM or ANM in East Asian women and to replicate previously identified loci primarily in women of European ancestry by genome-wide association studies (GWASs), we conducted a two-stage GWAS. Stage I aimed to discover promising novel AM and ANM loci using GWAS data of 8073 women from Shanghai, China. The Stage II replication study used the data from another Chinese GWAS (n = 1230 for AM and n = 1458 for ANM), a Korean GWAS (n = 4215 for AM and n = 1739 for ANM), and de novo genotyping of 2877 additional Chinese women. Previous GWAS-identified loci for AM and ANM were also evaluated. We identified two suggestive menarcheal age loci tagged by rs79195475 at 10q21.3 (beta = -0.118 years, P = 3.4 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.