ArticleJournal of autism and developmental disorders2016
Brief Report: Autism Symptoms in Infants with Fragile X Syndrome.
Article in Journal of autism and developmental disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- [Towards an early differential diagnosis in autism spectrum disorders and fragile X syndrome. A systematic review].Revista de neurologia · 2022Pooled it
- Development and validation of an early screening tool for young children with autism spectrum disorders: the checklist for Chinese toddlers with autism.Frontiers in psychiatry · 2026Article
- Contrasting Relationships Between Anxiety and Intolerance of Uncertainty in Cornelia de Lange and Fragile X Syndromes.Journal of intellectual disability research : JIDR · 2025Article
- Autism Observation Scale for Infants: Systematic Review and Meta-Analysis in Samples at Increased Likelihood of Autism Spectrum Disorders.Review journal of autism and developmental disorders · 2025Review
- Negative affect and respiratory sinus arrhythmia are differentially related to social anxiety and autism features in autistic preschoolers contrasted to fragile X syndrome.Frontiers in psychiatry · 2023Article
- Subcortical Brain Development in Autism and Fragile X Syndrome: Evidence for Dynamic, Age- and Disorder-Specific Trajectories in Infancy.The American journal of psychiatry · 2022Article
- Motor Influences on Communication: Comparisons Between Down Syndrome and Fragile X Syndrome.American journal on intellectual and developmental disabilities · 2021Article
- Emergence of Developmental Delay in Infants and Toddlers With anPediatrics · 2021Article
- Neural Correlates of Infant Face Processing and Later Emerging Autism Symptoms in Fragile X Syndrome.Frontiers in psychiatry · 2021Article
- Emergence and rate of autism in fragile X syndrome across the first years of life.Development and psychopathology · 2020Article
- Autism Spectrum Disorder-Associated Behaviour in Infants with Down Syndrome.Journal of health science & education · 2020Article
- Acoustic properties of early vocalizations in infants with fragile X syndrome.Autism research : official journal of the International Society for Autism Research · 2019Article
- Developmental divergence: motor trajectories in children with fragile X syndrome with and without co-occurring autism.Journal of neurodevelopmental disorders · 2019Article
- Social Avoidance Emerges in Infancy and Persists into Adulthood in Fragile X Syndrome.Journal of autism and developmental disorders · 2019Article
- Infant Social Avoidance Predicts Autism but Not Anxiety in Fragile X Syndrome.Frontiers in psychiatry · 2019Article
- Autism throughout genetics: Perusal of the implication of ion channels.Brain and behavior · 2018Review
- Early gesture use in fragile X syndrome.Journal of intellectual disability research : JIDR · 2018Article
- Behavioral Markers of Emergent Stranger Anxiety in Infants and Toddlers with Fragile X Syndrome.Journal of autism and developmental disorders · 2017Article
- Adaptive Skill Trajectories in Infants with Fragile X Syndrome Contrasted to Typical Controls and Infants at High Risk for Autism.Research in autism spectrum disorders · 2017Article
- Autism Spectrum Disorder Symptoms in Infants with Fragile X Syndrome: A Prospective Case Series.Journal of autism and developmental disorders · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Fragile X syndrome (FXS) is the most common known genetic cause of autism spectrum disorder (ASD). Although 50-75 % of children with FXS meet ASD criteria, no studies have compared ASD symptoms in infants with FXS versus other high risk groups, such as siblings of children with ASD (ASIBs). Using the Autism Observation Scale for Infants, our findings indicate that 53 % of 12-month infants with FXS fall in the "at risk" category compared to 17 and 6 % for age-matched ASIBs and controls, respectively. Elevated atypical motor behaviors were associated with elevated risk for FXS. Cross-syndrome comparisons are essential to understanding the heterogeneity of ASD and identifying candidate markers that will facilitate differential diagnosis of ASD in genetic disorders such as FXS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.