ArticleScientific reports2016
Double-Network Hydrogel with Tunable Mechanical Performance and Biocompatibility for the Fabrication of Stem Cells-Encapsulated Fibers and 3D Assemble.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 43 citations in OpenAlex.
- A bioprinted model of pregnant human uterine myometrium.Frontiers in bioengineering and biotechnology · 2025Article
- Toward robust and reproducible pluripotent stem cell expansion in bioprinted GelMA constructs.International journal of bioprinting · 2025Article
- Printing Double-Network Tough Hydrogels Using Temperature-Controlled Projection Stereolithography (TOPS).ACS applied materials & interfaces · 2023Article
- Three-Dimensional Printing of Double-Network Hydrogels: Recent Progress, Challenges, and Future Outlook.3D printing and additive manufacturing · 2022Review
- An overview of substrate stiffness guided cellular response and its applications in tissue regeneration.Bioactive materials · 2022Review
- The Importance of Interfaces in Multi-Material Biofabricated Tissue Structures.Advanced healthcare materials · 2021Review
- Environmentally responsive hydrogels for repair of cardiovascular tissue.Heart failure reviews · 2021Review
- Composable microfluidic spinning platforms for facile production of biomimetic perfusable hydrogel microtubes.Nature protocols · 2021Article
- Fast Switching of Bright Whiteness in Channeled Hydrogel Networks.Advanced functional materials · 2020Article
- Physical Organohydrogels With Extreme Strength and Temperature Tolerance.Frontiers in chemistry · 2020Article
- Tailoring supramolecular guest-host hydrogel viscoelasticity with covalent fibrinogen double networks.Journal of materials chemistry. B · 2019Article
- Stretchable Multiresponsive Hydrogel with Actuatable, Shape Memory, and Self-Healing Properties.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Article
- Hydrogel microfibers with perfusable folded channels for tissue constructs with folded morphology.RSC advances · 2018Article
- Micro 3D Printing of a Temperature-Responsive Hydrogel Using Projection Micro-Stereolithography.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fabrication of cell-encapsulated fibers could greatly contribute to tissue engineering and regenerative medicine. However, existing methods suffered from not only unavoidability of cell damaging conditions and/or sophisticated equipment, but also unavailability of proper materials to satisfy both mechanical and biological expectations. In this work, a simple method is proposed to prepare cell-encapsulated fibers with tunable mechanical strength and stretching behavior as well as diameter and microstructure. The hydrogel fibers are made from optimal combination of alginate and poly(N-iso-propylacrylamide)-poly(ethylene glycol), characteristics of double-network hydrogel, with enough stiffness and flexibility to create a variety of three dimensional structures like parallel helical and different knots without crack. Furthermore, such hydrogel fibers exhibit better compatibility as indicated by the viability, proliferation and expression of pluripotency markers of embryonic stem cells encapsulated after 4-day culture. The double-network hydrogel possesses specific quick responses to either of alginate lyase, EDTA or lower environmental temperature which facilitate the optional degradation of fibers or fibrous assemblies to release the cells encapsulated for subsequent assay or treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.