Evidence map›Paper›PMID 27628916›Full record

ArticleEnvironmental science and pollution research international2018

Hemochromatosis: a model of metal-related human toxicosis.

Pierre Brissot, Thibault Cavey, Martine Ropert, François Gaboriau, Olivier Loréal

Abstract read
PubMed Publisher
In one paragraph

Article in Environmental science and pollution research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Pierre BrissotHepatology, Faculty of Medicine, University of Rennes1, 2, avenue Pr. Léon BERNARD, 35043, Rennes, France. pierre.brissot@univ-rennes1.fr.
Thibault CaveyDepartment of Biochemistry, Pontchaillou University Hospital, Rennes, France.
Martine RopertDepartment of Biochemistry, Pontchaillou University Hospital, Rennes, France.
François GaboriauInserm-UMR 991, University of Rennes1, Rennes, France.
Olivier LoréalInserm-UMR 991, University of Rennes1, Rennes, France.
Université de Rennes · FRHôpital Pontchaillou · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many environmental agents, such as excessive alcohol intake, xenobiotics, and virus, are able to damage the human body, targeting especially the liver. Metal excess may also assault the liver. Thus, chronic iron overload may cause, especially when associated with cofactors, diffuse organ damage that is a source of significant morbidity and mortality. Iron excess can be either of acquired (mostly transfusional) or of genetic origin. Hemochromatosis is the archetype of genetic iron overload diseases and represents a serious health problem. A better understanding of iron metabolism has deeply modified the hemochromatosis field which today benefits from much more efficient diagnostic and therapeutic approaches.

Indexed as

HemochromatosisHumansIronIron OverloadLiverIronFerroportinHepcidinIron chelationIron overloadLabile plasma ironLipid peroxidationLiver fibrosisNon-transferrin bound ironReactive oxygen speciesTumorogenesisVenesection

Identifiers

PMID27628916
OpenAlexW2520189466

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.