Evidence map›Paper›PMID 27628595›Full record

ReviewMicrobial ecology2017

The Oral Microbiome of Children: Development, Disease, and Implications Beyond Oral Health.

Andres Gomez, Karen E Nelson

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Microbial ecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03236194 (Ancillary Microbiome Collection From Mother/Infant Pairs During First Year of Life), which is not on this map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03236194 completednot on this map

Ancillary Microbiome Collection From Mother/Infant Pairs During First Year of Life

TypeobservationalSponsorMilton S. Hershey Medical CenterRan2017 to 2019Enrolled100ConditionsInfant Development
3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 178 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Multicohort external validation ofFrontiers in cellular and infection microbiology · 2026
    Article
  7. Review
  8. Article
  9. Article
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  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
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  17. Article
  18. Review
  19. Migration Spurs Changes in the Human Microbiome: a Review.Journal of racial and ethnic health disparities · 2024
    Review
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Andres GomezDepartments of Human Biology and Genomic Medicine, J. Craig Venter Institute, La Jolla, 92037, CA, USA. agomez@jcvi.org.
Karen E NelsonDepartments of Human Biology and Genomic Medicine, J. Craig Venter Institute, La Jolla, 92037, CA, USA.
J. Craig Venter Institute · US

Funding

Metagenomics of the Microbiome in Oral Health and DiseaseR01DE019665 · NIDCR · J. CRAIG VENTER INSTITUTE, INC. · PI NELSON, KAREN E. · 2010 to 2014
$3.4M
NIDCR NIH HHS R01 DE019665
6 · The paper itself

Abstract

In the era of applied meta-omics and personalized medicine, the oral microbiome is a valuable asset. From biomarker discovery to being a powerful source of therapeutic targets and to presenting an opportunity for developing non-invasive approaches to health care, it has become clear that oral microbes may hold the answer for understanding disease, even beyond the oral cavity. Although our understanding of oral microbiome diversity has come a long way in the past 50 years, there are still many areas that need to be fine-tuned for better risk assessment and diagnosis, especially in early developmental stages of human life. Here, we discuss the factors that impact development of the oral microbiome and explore oral markers of disease, with a focus on the early oral cavity. Our ultimate goal is to put different experimental and methodological views into perspective for better assessment of early oral and systemic disease at an early age and discuss how oral microbiomes-at the community level-could provide improved assessment in individuals and populations at risk.

Indexed as

Oral HealthBacteriaBiodiversityBiomarkersChildDental CariesEcologyHumansMetagenomeMicrobiotaMouthMouth DiseasesRisk AssessmentRisk FactorsBiomarkersCariesChildrenMicrobial ecologyOral microbiome

Identifiers

PMID27628595
PMCPMC5274568
OpenAlexW2518999653

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.