Evidence map›Paper›PMID 27628237›Full record

SynthesisClinical reviews in allergy & immunology2017

Female Infertility and Serum Auto-antibodies: a Systematic Review.

Alban Deroux, Chantal Dumestre-Perard, Camille Dunand-Faure, Laurence Bouillet, Pascale Hoffmann

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical reviews in allergy & immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 4 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 4 syntheses or guidelines pooled it, 122 citations in OpenAlex.

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  14. The correlation between ANAs and pregnancy loss and their impact on IVF/ICSI-ET pregnancy outcomes in patients with recurrent pregnancy loss.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Alban DerouxInternal Medicine Department, Grenoble University Hospital, 38000, Grenoble, France. aderoux@chu-grenoble.fr.ORCID http://orcid.org/0000-0002-9098-7368
Chantal Dumestre-PerardImmunology Department, Laboratory Analysis and Pathology Institute, Grenoble University Hospital, 38000, Grenoble, France.
Camille Dunand-FaureGynecology and Obstetrics Department, Grenoble University Hospital, 38000, Grenoble, France.
Laurence BouilletInternal Medicine Department, Grenoble University Hospital, 38000, Grenoble, France.
Pascale HoffmannGynecology and Obstetrics Department, Grenoble University Hospital, 38000, Grenoble, France.
Centre Hospitalier Universitaire de Grenoble · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

On average, 10 % of infertile couples have unexplained infertility. Auto-immune disease (systemic lupus erythematosus, anti-phospholipid syndrome) accounts for a part of these cases. In the last 20 years, aspecific auto-immunity, defined as positivity of auto-antibodies in blood sample without clinical or biological criteria for defined diseases, has been evoked in a subpopulation of infertile women. A systematic review was performed (PUBMED) using the MESH search terms "infertility" and "auto-immunity" or "reproductive technique" or "assisted reproduction" or "in vitro fertilization" and "auto-immunity." We retained clinical and physiopathological studies that were applicable to the clinician in assuming joint management of both infertility associated with serum auto-antibodies in women. Thyroid auto-immunity which affects thyroid function could be a cause of infertility; even in euthyroidia, the presence of anti-thyroperoxydase antibodies and/or thyroglobulin are related to infertility. The presence of anti-phospholipid (APL) and/or anti-nuclear (ANA) antibodies seems to be more frequent in the population of infertile women; serum auto-antibodies are associated with early ovarian failure, itself responsible for fertility disorders. However, there exist few publications on this topic. The methods of dosage, as well as the clinical criteria of unexplained infertility deserve to be standardized to allow a precise response to the question of the role of serum auto-antibodies in these women. The direct pathogenesis of this auto-immunity is unknown, but therapeutic immunomodulators, prescribed on a case-by-case basis, could favor pregnancy even in cases of unexplained primary or secondary infertility.

Indexed as

Adrenal GlandsAntibodies, AntinuclearAntibodies, AntiphospholipidAutoantibodiesAutoimmunityEndometriumFemaleFertilization in VitroHumansInfertility, FemaleOvaryPregnancyReproductive Techniques, AssistedTrophoblastsAntibodies, AntinuclearAntibodies, AntiphospholipidAutoantibodiesAnti-nuclear antibodiesAnti-phospholipid antibodiesAssisted reproductionAuto-immunityImmunomodulatorInfertilityReproductive techniqueSerum auto-antibodies

Identifiers

PMID27628237
OpenAlexW2520168912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.