Evidence map›Paper›PMID 27628106›Full record

ArticleDiabetologia2016

Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice.

Troy L Merry, Melanie Tran, Garron T Dodd, Salvatore P Mangiafico, Florian Wiede, Supreet Kaur, Catriona L McLean, Sofianos Andrikopoulos, Tony Tiganis

Erratum issuedOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Diabetologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Troy L MerryMetabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Melanie TranMetabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Garron T DoddMetabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Salvatore P MangiaficoDepartment of Medicine (Austin Hospital), The University of Melbourne, Melbourne, VIC, Australia.
Florian WiedeMetabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Supreet KaurMetabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Catriona L McLeanDepartment of Anatomical Pathology, Alfred Hospital, Prahran, VIC, Australia.
Sofianos AndrikopoulosDepartment of Medicine (Austin Hospital), The University of Melbourne, Melbourne, VIC, Australia.
Tony TiganisMetabolic Disease and Obesity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia. Tony.Tiganis@monash.edu.
Monash University · AUAustin Hospital · AUAustralian Regenerative Medicine Institute · AUThe Alfred Hospital · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisIn obesity oxidative stress is thought to contribute to the development of insulin resistance, non-alcoholic fatty liver disease and the progression to non-alcoholic steatohepatitis. Our aim was to examine the precise contributions of hepatocyte-derived H

methodsGlutathione peroxidase (GPX) 1 is an antioxidant enzyme that is abundant in the liver and converts H

resultsChow-fed Alb-Cre;Gpx1 CONCLUSIONS/

interpretationIncreased hepatocyte-derived H

Indexed as

AllelesAnimalsDiabetes Mellitus, Type 2Fatty LiverGlucoseGlutathione PeroxidaseGlutathione Peroxidase GPX1HepatocytesHydrogen PeroxideInsulin ResistanceLiverMaleMiceMice, Inbred C57BLMice, KnockoutNon-alcoholic Fatty Liver DiseaseGlucoseGlutathione PeroxidaseGlutathione Peroxidase GPX1Gpx1 protein, mouseHydrogen PeroxideProtein Tyrosine PhosphatasesReactive Oxygen SpeciesFibrosisGlutathione peroxidase-1HepatocyteInflammationInsulin resistanceNon-alcoholic fatty liver diseaseNon-alcoholic steatohepatitisProtein tyrosine phosphataseReactive oxygen speciesType 2 diabetes

Identifiers

PMID27628106
OpenAlexW2521008492

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.