ArticleHuman brain mapping2017
The Temporal Instability of Resting State Network Connectivity in Intractable Epilepsy.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Static and dynamic intracerebral signal analysis reveals protective networks against seizures in drug-resistant focal epilepsy.Brain communications · 2026Article
- Motor and default mode network states of rest in frontal lobe epilepsy.Neuroimage. Reports · 2025Article
- Altered static and dynamic functional network connectivity in individuals with subthreshold depression: a large-scale resting-state fMRI study.European archives of psychiatry and clinical neuroscience · 2025Article
- Intrinsic brain network stability during kainic acid-induced epileptogenesis.Epilepsia open · 2025Article
- Current State of Functional MRI in the Presurgical Planning of Brain Tumors.Radiology. Imaging cancer · 2023Review
- Regional and remote connectivity patterns in focal extratemporal lobe epilepsy.Annals of translational medicine · 2021Article
- Abnormal Static and Dynamic Functional Connectivity in Left and Right Temporal Lobe Epilepsy.Frontiers in neuroscience · 2021Article
- Decreased Intrinsic Neural Timescales in Mesial Temporal Lobe Epilepsy.Frontiers in human neuroscience · 2021Article
- Dynamic connectivity predicts acute motor impairment and recovery post-stroke.Brain communications · 2021Article
- Alterations in intra- and internetwork functional connectivity associated with levetiracetam treatment in temporal lobe epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Frequency-specific changes in the default mode network in patients with cingulate gyrus epilepsy.Human brain mapping · 2020Article
- Respiratory-related brain pulsations are increased in epilepsy-a two-centre functional MRI study.Brain communications · 2020Article
- Time-resolved connectome of the five-factor model of personality.Scientific reports · 2019Article
- Altered intrinsic brain activity associated with outcome in frontal lobe epilepsy.Scientific reports · 2019Article
- Juvenile myoclonic epilepsy has hyper dynamic functional connectivity in the dorsolateral frontal cortex.NeuroImage. Clinical · 2019Article
- Altered Functional Connectivity in Children With Low-Function Autism Spectrum Disorders.Frontiers in neuroscience · 2019Article
- Intermittent Theta-Burst Stimulation Reverses the After-Effects of Contralateral Virtual Lesion on the Suprahyoid Muscle Cortex: Evidence From Dynamic Functional Connectivity Analysis.Frontiers in neuroscience · 2019Article
- Altered physiological brain variation in drug-resistant epilepsy.Brain and behavior · 2018Article
- Cognition and dementia in older patients with epilepsy.Brain : a journal of neurology · 2018Review
- Altered Default Mode Network on Resting-State fMRI in Children with Infantile Spasms.Frontiers in neurology · 2017Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveFocal epilepsies, such as temporal lobe epilepsy (TLE), are known to disrupt network activity in areas outside the epileptogenic zone [Tracy et al., 2015]. We devised a measure of temporal instability of resting state functional connectivity (FC), capturing temporal variations of BOLD correlations between brain regions that is less confounded than the "sliding window" approach common in the literature.
methodsWe investigated healthy controls and unilateral TLE patients (right and left seizure focus groups), utilizing group ICA to identify the default mode network (DMN), a network associated with episodic memory, a key cognitive deficit in TLE. Our instability analyses focused on: (1) connectivity between DMN region pairs, both within and between TLE patients and matched controls, (2) whole brain group differences between region pairs ipsilateral or contralateral to the epileptogenic temporal lobe.
resultsFor both the whole brain and a more focused analysis of DMN region pairs, temporal stability appears to characterize the healthy brain. The TLE patients displayed more FC instability compared to controls, with this instability more pronounced for the right TLE patients. SIGNIFICANCE: Our findings challenge the view that the resting state signal is stable over time, providing a measure of signal coherence change that may generate insights into the temporal components of network organization. The precuneus was the region within the DMN consistently expressing this instability, suggesting this region plays a key role in large scale temporal dynamics of the DMN, with such dynamics disrupted in TLE, putting key cognitive functions at risk. Hum Brain Mapp 38:528-540, 2017. © 2016 Wiley Periodicals, Inc.
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