Evidence map›Paper›PMID 27627870›Full record

ArticleJournal of medical primatology2016

Pregnancy-driven cardiovascular maternal miR-29 plasticity in obesity.

N Schlabritz-Loutsevitch, K Apostolakis-Kyrus, R Krutilina, G Hubbard, M Kocak, Z Janjetovic, S Sathanandam, A T Slominski, G Mari, E Dick

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical primatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

N Schlabritz-LoutsevitchDepartment of Obstetrics and Gynecology, Texas Tech University Health Sciences Center at the Permian Basin, Odessa, TX, USA.
K Apostolakis-KyrusDepartment of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN, USA.
R KrutilinaDepartment of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
G HubbardDepartment of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
M KocakDivision of Biostatistics and Epidemiology, Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Z JanjetovicDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.
S SathanandamDivision of Pediatric Cardiology, University of Tennessee Health Science Center, Memphis, TN, USA.
A T SlominskiDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.
G MariDepartment of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN, USA.
E DickSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
University of Tennessee Health Science Center · USUniversity of Alabama at Birmingham · USTexas Biomedical Research Institute · USTexas Tech University Health Sciences Center · USThe University of Texas Health Science Center at San Antonio · US

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
WNV REPLIVAX VACCINE IN NON-HUMAN PRIMATESP51RR013986 · NCRR · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI GOLDBERG, ERWIN · 1999 to 2011
$79.1M
PARTURITION AND FETAL PRIMATE HYPOTHALAMIC FUNCTIONP01HD021350 · NICHD · UNIVERSITY OF WYOMING · PI MCDONALD, THOMAS JOSEPH · 1987 to 2018
$19.9M
Registry And Data AnalysisP50HL084922 · NHLBI · WASHINGTON UNIVERSITY · PI GIERADA, DAVID S · 2007 to 2011
$14.0M
Role of Exogenous Melatonin in Skin BiologyR01AR056666 · NIAMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SLOMINSKI, ANDRZEJ T · 2011 to 2015
$1.6M
EXTRAMURAL RES FACILITIES CONSTRC06RR015456 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI VANDEBERG, JOHN L · 2001 to 2001
$1.1M
Mechanism of action of 20-hydroxyvitamin D3 in dermal fibroblastsR21AR066505 · NIAMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SLOMINSKI, ANDRZEJ T · 2014 to 2015
$355k
BABOON F-CAGE FACILITY FOR PRIMATE RESEARCH CENTERC06RR014578 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI VANDEBERG, JOHN L · 1999 to 1999
–
NCRR NIH HHS C06 RR014578NCRR NIH HHS C06 RR015456NCRR NIH HHS P51 RR013986NHLBI NIH HHS P50 HL084922NIAMS NIH HHS R01 AR056666NIAMS NIH HHS R21 AR066505NICHD NIH HHS P01 HD021350NIH HHS P51 OD011133
6 · The paper itself

Abstract

backgroundObesity in pregnancy (MO) is a risk factor for maternal and/or fetal cardiovascular system disorders. This study evaluated maternal CVS expression of microRNA-29 family and its target molecules in MO to test the hypotheses: CVS miR-29 concentrations are increased in pregnancy and decreased in MO.

methodsNon-pregnant (n=4), pregnant obese (POb, n=4), and pregnant non-obese (PnOb, n=4) baboons (Papio spp.) were studied. Maternal left ventricle (LV), left atrium (LA), and aortic arch (AA) were collected at the end of gestation. Expression of MiR-29 and elastin (ELN) mRNA were quantified.

resultsLA miR-29 (a, c) expression was highest in PnOb. In the LV, miR-29b expression trended lower (P=.059) for PnOb animals. ELN mRNA expression correlated positively with miR-29b expression in AA (r=.76, P=.03).

conclusionMaternal obesity diminishes miR-29 adaptation to pregnancy. Pharmacologic, tissue-specific targeting of miRNA-29 may represent a strategy for prevention and treatment of MO complications.

Indexed as

PapioAnimalsFemaleMicroRNAsMonkey DiseasesMyocardiumObesityPregnancyMicroRNAsmaternal obesitynon-human primatevascular remodeling

Identifiers

PMID27627870
PMCPMC5352555
OpenAlexW2519032756

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.