ArticleComparative biochemistry and physiology. Part B, Biochemistry & molecular biology2017
Pyrethroid-resistance is modulated by miR-92a by targeting CpCPR4 in Culex pipiens pallens.
Article in Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Review
- Insights into the role of non-coding RNAs in the development of insecticide resistance in insects.Frontiers in genetics · 2024Review
- MiR-279-3p regulates deltamethrin resistance through CYP325BB1 in Culex pipiens pallens.Parasites & vectors · 2021Article
- Development of miRNA-Based Approaches to Explore the Interruption of Mosquito-Borne Disease Transmission.Frontiers in cellular and infection microbiology · 2021Review
- Profiling of MicroRNAs in Midguts ofFrontiers in genetics · 2021Article
- A systemic study of indoxacarb resistance in Spodoptera litura revealed complex expression profiles and regulatory mechanism.Scientific reports · 2019Article
- A novel miRNA, miR-13664, targets CpCYP314A1 to regulate deltamethrin resistance in Culex pipiens pallens.Parasitology · 2019Article
- Plant-Derived Essential Oils; Their Larvicidal Properties and Potential Application for Control of Mosquito-Borne Diseases.Galen medical journal · 2019Review
- Impacts of Sub-lethal DDT Exposures on microRNA and Putative Target Transcript Expression in DDT Resistant and SusceptibleFrontiers in genetics · 2019Article
- Culex pipiens pallens cuticular protein CPLCG5 participates in pyrethroid resistance by forming a rigid matrix.Parasites & vectors · 2018Article
- Identification of Differentially Expressed miRNAs in Colorado Potato Beetles (Leptinotarsa decemlineata (Say)) Exposed to Imidacloprid.International journal of molecular sciences · 2017Article
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Authors and funding
8 authors.
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Abstract
The wide use of pyrethroids has resulted in the emergence and spread of resistance in mosquito populations, which represent a major obstacle in the struggle against vector-borne diseases. Resistance to pyrethroids is a complex genetic phenomenon attributed by polygenetic inheritance. We previously have sequenced and analyzed the miRNA profiles of Culex pipiens pallens. MiR-92a was found to be overexpressed in a deltamethrin-resistant (DR) strain. The association of miR-92a with pyrethroid-resistance was investigated by quantitative reverse transcription PCR (qRT-PCR). Expression levels of miR-92a were 2.72-fold higher in the DR strain than in the deltamethrin-susceptible (DS) strain. Bioinformatic analysis suggested that CpCPR4, a mosquito cuticle gene, is the target of miR-92a. Dual luciferase reporter assays further confirmed that CpCPR4 is modulated by miR-92a through binding to a specific target site in the 3' untranslated region (3' UTR). Microinjection of the miR-92a inhibitor upregulated CpCPR4 expression levels, leading to an increase in the susceptibility of the DR strain in the Centers for Disease Control and Prevention (CDC) bottle bioassay (a surveillance tool for detecting resistance to insecticides in vector populations). Taken together, our findings indicate that miR-92a regulates pyrethroid-resistance through its interaction with CpCPR4.
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