Evidence map›Paper›PMID 27627640›Full record

ArticleArquivos brasileiros de cardiologia2016

Hypomethylation of Interleukin-6 Promoter is Associated with the Risk of Coronary Heart Disease.

Hong-Peng Zuo, Ying-Yu Guo, Lin Che, Xian-Zheng Wu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arquivos brasileiros de cardiologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
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  14. Frontiers in genetics · 2022
    Article
  15. The Epigenome in Atherosclerosis.Handbook of experimental pharmacology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Hong-Peng ZuoDepartment of Emergency, Tongji Hospital, Tongji University, Shanghai, China.
Ying-Yu GuoDepartment of Computed Tomography, Jilin Oilfield General Hospital, Songyuan, Jilin Province, China.
Lin CheDepartment of Cardiology, Tongji Hospital, Tongji University, Shanghai, China.
Xian-Zheng WuDepartment of Emergency, Tongji Hospital, Tongji University, Shanghai, China.
Daqing Oilfield General Hospital · CNTongji Hospital · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInterleukin-6 (IL-6) is implicated in the pathogenesis of coronary heart disease (CHD), and IL-6 expression has associated with reduced DNA methylation of its gene promoter. However, there are no data on IL-6 promoter methylation and the risk of CHD.

objectiveTo examine whether IL-6 promoter methylation measured in blood leukocyte DNA is associated with CHD risk.

methodsA total of 212 cases with CHD and 218 controls were enrolled. Methylation at two CpG sites in IL-6 promoter was measured by bisulfite pyrosequencing, and the mean IL-6 methylation was calculated by averaging the methylation measures of the two CpGs.

resultsMean methylation level in IL-6 promoter in CHD cases was significantly lower than that in controls (p = 0.023). Logistic regression analysis showed that IL-6 methylation was inversely associated with the risk of CHD. The odds ratios (ORs) of CHD for subjects in the second and first (lowest) tertile of IL-6 methylation were 1.87 (95% CI = 1.10‑3.20) and 2.01 (95% CI = 1.19-3.38) (ptrend = 0.013), respectively, compared to subjects in the third (highest) tertile. The IL-6 hypomethylation-related risk estimates tended to be stronger for acute myocardial infarction (ptrend = 0.006). CpG position-specific analysis showed that hypomethylation of position 1 conferred a more pronounced increase in CHD risk than that of position 2.

conclusionThese findings suggest that DNA hypomethylation of IL-6 promoter is associated with the increased risk for CHD, especially for acute myocardial infarction. The two distinct CpGs in IL-6 may contribute differently to the development of CHD.

Indexed as

CpG IslandsDNA MethylationPromoter Regions, GeneticAgedAngina, UnstableCoronary DiseaseFemaleGenetic Predisposition to DiseaseHumansInterleukin-6LeukocytesMaleMyocardial InfarctionSequence Analysis, DNAInterleukin-6

Identifiers

PMID27627640
PMCPMC5074066
OpenAlexW2529645812

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.