Evidence map›Paper›PMID 27627578›Full record

ArticleNatural product research2017

Cytotoxic halogenated monoterpenes from Plocamium cartilagineum.

Omar M M Sabry, Douglas E Goeger, Frederick A Valeriote, William H Gerwick

Open access · greenAbstract read
In one paragraph

Article in Natural product research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Frontiers in oncology · 2026
    Article
  2. Article
  3. Article
  4. Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023
    Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Omar M M Sabrya College of Pharmacy , Oregon State University , Corvallis , OR , USA.
Douglas E Goegera College of Pharmacy , Oregon State University , Corvallis , OR , USA.
Frederick A Valeriotec Division of Hematology and Oncology Department of Internal Medicine , Henry Ford Hospital , Detroit , MI , USA.
William H Gerwicka College of Pharmacy , Oregon State University , Corvallis , OR , USA.
Oregon State University · USHenry Ford Hospital · USScripps Institution of Oceanography · US

Funding

Targeted Discovery of Marine-derived Anticancer LeadsU19CA052955 · NCI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI WRIGHT, AMY ELIZABETH · 1995 to 2009
$9.7M
NOVEL CYTOTOXIC NATURAL PRODUCTS FROM MARINE SPONGESR01CA047135 · NCI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CREWS, PHIL, VALERIOTE, FREDERICK AUGUSTUS · 1989 to 2017
$8.1M
Neurotoxins from Marine Algae and CyanobacteriaR01GM063554 · NIGMS · OREGON STATE UNIVERSITY · PI GERWICK, WILLIAM H · 2001 to 2004
$1.1M
NCI NIH HHS R01 CA047135NCI NIH HHS U19 CA052955NIGMS NIH HHS R01 GM063554
6 · The paper itself

Abstract

As a result of our efforts to identify bioactive agents from marine algae, we have isolated and identified one new halogenated monoterpene 1 [(-)-(5E,7Z)-348-trichloro-7-dichloromethyl-3-methyl-157-octatriene] in addition to three known compounds (2, 3 and 4) from the red alga Plocamium cartilagineum collected by hand from the eastern coast of South Africa. Compound 1 was found to be active as a cytotoxic agent in human lung cancer (NCI-H460) and mouse neuro-2a cell lines (IC

Indexed as

AnimalsAntineoplastic AgentsCell Line, TumorColonic NeoplasmsHalogenationHumansLeukemiaLung NeoplasmsMagnetic Resonance SpectroscopyMiceMolecular StructureMonoterpenesPlocamiumSpectrum AnalysisAntineoplastic AgentsMonoterpenesHalogenated monoterpeneshuman colon cancershuman leukaemiahuman lung cancersPlocamium cartilagineum

Identifiers

PMID27627578
PMCPMC5748142
OpenAlexW2518952383

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.