ArticlePhysical review. E2016
Phase-plane analysis of the totally asymmetric simple exclusion process with binding kinetics and switching between antiparallel lanes.
Article in Physical review. E, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Agitated ants: regulation and self-organization of incipient nest excavation via collisional cues.Journal of the Royal Society, Interface · 2023Article
- Motor guidance by long-range communication on the microtubule highway.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Modeling spatiotemporally varying protein-protein interactions in CyLaKS, the Cytoskeleton Lattice-based Kinetic Simulator.The European physical journal. E, Soft matter · 2021Article
- EGGTART: A tool to visualize the dynamics of biophysical transport under the inhomogeneous l-TASEP.Biophysical journal · 2021Article
- Motor Protein Accumulation on Antiparallel Microtubule Overlaps.Biophysical journal · 2016Article
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Authors and funding
2 authors.
Funding
Abstract
Motor protein motion on biopolymers can be described by models related to the totally asymmetric simple exclusion process (TASEP). Inspired by experiments on the motion of kinesin-4 motors on antiparallel microtubule overlaps, we analyze a model incorporating the TASEP on two antiparallel lanes with binding kinetics and lane switching. We determine the steady-state motor density profiles using phase-plane analysis of the steady-state mean field equations and kinetic Monte Carlo simulations. We focus on the density-density phase plane, where we find an analytic solution to the mean field model. By studying the phase-space flows, we determine the model's fixed points and their changes with parameters. Phases previously identified for the single-lane model occur for low switching rate between lanes. We predict a multiple coexistence phase due to additional fixed points that appear as the switching rate increases: switching moves motors from the higher-density to the lower-density lane, causing local jamming and creating multiple domain walls. We determine the phase diagram of the model for both symmetric and general boundary conditions.
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