ArticlePloS one2016
Analysis of Patients with Helicobacter pylori Infection and the Subsequent Risk of Developing Osteoporosis after Eradication Therapy: A Nationwide Population-Based Cohort Study.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Effect of polyphenol compounds onBMJ open · 2023Pooled it
- Preventive Effect ofGut and liver · 2026Observational
- The association between Helicobacter pylori and osteoporosis: the mediating effect of inflammation.Gut pathogens · 2026Article
- Exploring molecular links between obesity and osteoporosis: insights from in-silico analysis and mannose supplementation.Scientific reports · 2025Article
- Establishing the Association Between Osteoporosis and Peptic Ulcer Disease: A Systematic Review.Cureus · 2022Review
- Bone Fragility in Gastrointestinal Disorders.International journal of molecular sciences · 2022Review
- Association of Helicobacter pylori infection with osteoporosis risk in a physical examination population.Archives of osteoporosis · 2022Article
- Effect of sequential eradication therapy on serum osteoprotegerin levels in patients withThe Journal of international medical research · 2021Observational
- Is the Occurrence or Reversal of Nonalcoholic Fatty Liver Disease Associated with Long-Term Helicobacter pylori Infection among Chinese Adults? A Cohort Study.Gastroenterology research and practice · 2021Article
- Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review).Journal of clinical medicine · 2020Review
- H. Pylori is related to osteoporosis but only in premenopausal female: a cross-sectional study.BMC musculoskeletal disorders · 2020Article
- Association of gout with CAD and effect of antigout therapy on CVD risk among gout patients.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2020Article
- Role of Helicobacter pylori infection in the manifestation of old age-related diseases.Molecular genetics & genomic medicine · 2020Review
- Bone of Contention: Helicobacter pylori and Osteoporosis-Is There an Association?Digestive diseases and sciences · 2019Review
- Relationship between Helicobacter pylori infection and bone mineral density: a retrospective cross-sectional study.BMC gastroenterology · 2018Article
- Correlation betweenGastroenterology research and practice · 2018Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePrevious studies have reported conflicting results on the association between Helicobacter pylori infection and osteoporosis. A few studies have discussed the influence of H. pylori eradication therapy on bone mineral density.
methodsWe assessed the prevalence of osteoporosis among the H. pylori-infected population in Taiwan and the influence of early and late H. pylori eradication therapy on bone mineral density.
resultsUsing data from Taiwan's National Health Insurance Research Database, we identified 5,447 patients who received H. pylori eradication therapy from 2000 to 2010 and 21,788 controls, frequency-matched according to age, sex, and year of receiving H. pylori eradication therapy. Those who received H. pylori eradication therapy were divided into two groups based on the time interval between the diagnosis of a peptic ulcer and commencement of eradication therapy. The risk of developing osteoporosis was higher in the early H. pylori treatment cohort (hazard ratio [HR] = 1.52, 95% confidence interval [CI] = 1.23-1.89) and late H. pylori treatment cohort (HR = 1.69, 95% CI = 1.39-2.05), compared with the risk in the control cohort. When followed for less than 5 years, both the early and late cohorts had a higher risk of developing osteoporosis (HR = 1.69, 95% CI = 1.32-2.16 and HR = 1.72, 95% CI = 1.38-2.14). However, when the follow-up period was over 5 years, only the late eradication group exhibited a higher incidence of osteoporosis (HR = 1.62, 95% CI = 1.06-2.47).
conclusionThe development of osteoporosis is complex and multi-factorial. Via this population-based cohort study and adjustment of possible confounding variables, we found H. pylori infection may be associated with an increased risk of developing osteoporosis in Taiwan. Early eradication could reduce the influence of H. pylori infection on osteoporosis when the follow-up period is greater than 5 years. Further prospective studies are necessary to discover the connection of H. pylori and osteoporosis.
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