ArticlePLoS computational biology2016
SUMOFLUX: A Generalized Method for Targeted 13C Metabolic Flux Ratio Analysis.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Acetol biosynthesis enables NADPH balance during nitrogen limitation in engineered Escherichia coli.Microbial cell factories · 2025Article
- FreeFlux: A Python Package for Time-Efficient Isotopically Nonstationary Metabolic Flux Analysis.ACS synthetic biology · 2023Article
- Metabolic flux analysis: a comprehensive review on sample preparation, analytical techniques, data analysis, computational modelling, and main application areas.RSC advances · 2022Review
- Isotope Calculation Gadgets: A Series of Software for Isotope-Tracing Experiments in Garuda Platform.Metabolites · 2022Article
- Hot isopropanol quenching procedure for automated microtiter plate scaleMicrobial cell factories · 2022Article
- Review
- Metabolomics in infectious diseases and drug discovery.Molecular omics · 2021Review
- Stable Isotopes for Tracing Cardiac Metabolism in Diseases.Frontiers in cardiovascular medicine · 2021Review
- Tracing metabolic flux through time and space with isotope labeling experiments.Current opinion in biotechnology · 2020Review
- Article
- Machine Learning Applications for Mass Spectrometry-Based Metabolomics.Metabolites · 2020Review
- DynamiciScience · 2020Article
- The era of big data: Genome-scale modelling meets machine learning.Computational and structural biotechnology journal · 2020Review
- Staring into the void: demystifying microbial metabolomics.FEMS microbiology letters · 2019Article
- The Design of FluxML: A Universal Modeling Language forFrontiers in microbiology · 2019Article
- The challenge and potential of photosynthesis: unique considerations for metabolic flux measurements in photosynthetic microorganisms.Biotechnology letters · 2019Review
- Estimation of flux ratios without uptake or release data: Application to serine and methionine metabolism.Metabolic engineering · 2017Article
- Article
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Authors and funding
2 authors.
Funding
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Abstract
Metabolic fluxes are a cornerstone of cellular physiology that emerge from a complex interplay of enzymes, carriers, and nutrients. The experimental assessment of in vivo intracellular fluxes using stable isotopic tracers is essential if we are to understand metabolic function and regulation. Flux estimation based on 13C or 2H labeling relies on complex simulation and iterative fitting; processes that necessitate a level of expertise that ordinarily preclude the non-expert user. To overcome this, we have developed SUMOFLUX, a methodology that is broadly applicable to the targeted analysis of 13C-metabolic fluxes. By combining surrogate modeling and machine learning, we trained a predictor to specialize in estimating flux ratios from measurable 13C-data. SUMOFLUX targets specific flux features individually, which makes it fast, user-friendly, applicable to experimental design and robust in terms of experimental noise and exchange flux magnitude. Collectively, we predict that SUMOFLUX's properties realistically pave the way to high-throughput flux analyses.
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Registered trials
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