ArticleMarine drugs2016
Bioprospecting Red Sea Coastal Ecosystems for Culturable Microorganisms and Their Antimicrobial Potential.
Article in Marine drugs, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Marine Microbes: A Source of Novel Antibiotics against Antimicrobial-resistant (AMR) Pathogens: A Systematic Review.Current drug targets · 2026Pooled it
- Genomic insights into the mangrove-associated cultivable bacteria and their ecological function.iScience · 2025Article
- Novel Anti-MRSA Peptide from Mangrove-DerivedMarine drugs · 2025Article
- Comprehensive genomic analysis ofComputational and structural biotechnology journal · 2023Article
- Microbial Diversity in the Indian Ocean Sediments: An Insight into the Distribution and Associated Factors.Current microbiology · 2022Review
- Article
- Multiple strain analysis of Streptomyces species from Philippine marine sediments reveals intraspecies heterogeneity in antibiotic activities.Scientific reports · 2021Article
- Insights into the Variation in Bioactivities of Closely RelatedMarine drugs · 2021Article
- Review
- Identification and characterization of antimicrobial peptide produced by indigenously isolated3 Biotech · 2020Article
- Comparative genomics study reveals Red Sea Bacillus with characteristics associated with potential microbial cell factories (MCFs).Scientific reports · 2019Article
- Bioprospecting desert plant Bacillus endophytic strains for their potential to enhance plant stress tolerance.Scientific reports · 2019Article
- Mining biosynthetic gene clusters in Virgibacillus genomes.BMC genomics · 2019Article
- Insights into Red Sea Brine Pool Specialized Metabolism Gene Clusters Encoding Potential Metabolites for Biotechnological Applications and Extremophile Survival.Marine drugs · 2019Article
- Microbial embryonal colonization during pipefish male pregnancy.Scientific reports · 2019Article
- Genome sequence analysis ofBiotechnology reports (Amsterdam, Netherlands) · 2018Article
- In silico exploration of Red Sea Bacillus genomes for natural product biosynthetic gene clusters.BMC genomics · 2018Article
- Building a bio-based industry in the Middle East through harnessing the potential of the Red Sea biodiversity.Applied microbiology and biotechnology · 2017Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microorganisms that inhabit unchartered unique soil such as in the highly saline and hot Red Sea lagoons on the Saudi Arabian coastline, represent untapped sources of potentially new bioactive compounds. In this study, a culture-dependent approach was applied to three types of sediments: mangrove mud (MN), microbial mat (MM), and barren soil (BS), collected from Rabigh harbor lagoon (RHL) and Al-Kharrar lagoon (AKL). The isolated bacteria were evaluated for their potential to produce bioactive compounds. The phylogenetic characterization of 251 bacterial isolates based on the 16S rRNA gene sequencing, supported their assignment to five different phyla: Proteobacteria, Firmicutes, Actinobacteria, Bacteroidetes, and Planctomycetes. Fifteen putative novel species were identified based on a 16S rRNA gene sequence similarity to other strain sequences in the NCBI database, being ≤98%. We demonstrate that 49 of the 251 isolates exhibit the potential to produce antimicrobial compounds. Additionally, at least one type of biosynthetic gene sequence, responsible for the synthesis of secondary metabolites, was recovered from 25 of the 49 isolates. Moreover, 10 of the isolates had a growth inhibition effect towards Staphylococcus aureus, Salmonella typhimurium and Pseudomonas syringae. We report the previously unknown antimicrobial activity of B. borstelensis, P. dendritiformis and M. salipaludis against all three indicator pathogens. Our study demonstrates the evidence of diverse cultured microbes associated with the Red Sea harbor/lagoon environments and their potential to produce antimicrobial compounds.
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