ReviewExpert review of anti-infective therapy2016
Global challenges in human immunodeficiency virus and syphilis coinfection among men who have sex with men.
Review in Expert review of anti-infective therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Sexually transmitted infection prevalence and testing coverage among people who inject drugs: A systematic review.Drug and alcohol dependence · 2025Pooled it
- IL-10 and IL-17 as Progression Markers of Syphilis in People Living with HIV: A Systematic Review.Biomolecules · 2022Pooled it
- Secondary Distribution of Dual HIV/Syphilis Self-Testing Among Men Who Have Sex With Men: Pragmatic Randomized Controlled Trial in China.JMIR public health and surveillance · 2025Trial
- Expanding syphilis test uptake using rapid dual self-testing for syphilis and HIV among men who have sex with men in China: A multiarm randomized controlled trial.PLoS medicine · 2022Trial
- Syphilis-related mortality in the United States, 2021-2025: trends, demographic disparities, and clinical implications.BMC infectious diseases · 2026Article
- Successful Scale-up of Syphilis Testing Linked to Routine HIV Viral Load Monitoring in British Columbia.Open forum infectious diseases · 2026Article
- Clinical Characteristics and Risk Factors for Syphilis Among People Living With Human Immunodeficiency Virus: A Nationwide Population-Based Cohort Study in Korea.Journal of Korean medical science · 2026Article
- Do Sexually Transmitted Infections Coexist? Evidence from Human Immunodeficiency Virus and Syphilis Coinfection in a Tertiary Care Center.Journal of clinical practice and research · 2026Article
- Serum Cytokines and TGF-β1: A Window into Syphilis Among People Living with HIV.Pathogens (Basel, Switzerland) · 2026Article
- Clinical manifestations and serological rebound in HIV and syphilis co-infection: a case report and literature review.AIDS research and therapy · 2026Review
- Article
- Validity of dried blood spot testing for sexually transmitted and blood-borne infections: A narrative systematic review.PLOS global public health · 2024Article
- Oral Secondary Syphilis in an HIV-Positive Transgender Patient: A Case Report and Review of the Literature.Dentistry journal · 2023Article
- Lifetime prevalence of syphilis infection among predominantly Black sexual and gender minorities living with HIV in Atlanta, Georgia: a cross-sectional analysis.Ethnicity & health · 2023Article
- Clinical and immunological characteristics of HIV/syphilis co-infected patients following long-term antiretroviral treatment.Frontiers in public health · 2023Article
- Syphilis Self-testing: A Nationwide Pragmatic Study Among Men Who Have Sex With Men in China.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Immunological Changes in Monocyte Subsets and Their Association With Foxp3Frontiers in immunology · 2019Article
- New Surge of Syphilis among Patients Living with Human Immunodeficiency Virus in Martinique in 2015.The American journal of tropical medicine and hygiene · 2017Article
- Syphilis Infection Differentially Regulates the Phenotype and Function of γδ T Cells in HIV-1-Infected Patients Depends on the HIV-1 Disease Stage.Frontiers in immunology · 2017Article
- Proportion of syphilis and hepatitis B and C virus infections among the Integrated Counselling and Testing Centre attendees of a tertiary care hospital.Indian journal of sexually transmitted diseases and AIDSArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
introductionSyphilis and human immunodeficiency virus (HIV) coinfection disproportionately affects men who have sex with men (MSM), and the rate of coinfection has been increasing over the last decade. HIV and syphilis coinfection is particularly challenging because the infections interact synergistically thereby increasing the risk of acquisition and transmission as well as accelerating disease progression. Areas covered: This paper reviews and summarizes the epidemiology, pathogenesis, diagnosis, clinical management and prevention of HIV and syphilis coinfection among MSM. Expert commentary: Research does not support a different syphilis treatment for coinfected individuals; however, coinfection may warrant a recommendation for antiretroviral therapy. In order to reverse the epidemic of syphilis and HIV coinfection, there needs to be greater awareness, improved cultural sensitivity among health care providers, improved access to preventative services and increased screening for syphilis and HIV.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.