ArticlePLoS computational biology2016
A Model of the Spatio-temporal Dynamics of Drosophila Eye Disc Development.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Feedback control of organ size precision is mediated by BMP2-regulated apoptosis in the Drosophila eye.PLoS biology · 2024Article
- Hedgehog morphogen gradient is robust towards variations in tissue morphology in Drosophila.Scientific reports · 2023Article
- Rare EIF4A2 variants are associated with a neurodevelopmental disorder characterized by intellectual disability, hypotonia, and epilepsy.American journal of human genetics · 2023Article
- Patterning of theFrontiers in cell and developmental biology · 2023Review
- Precision of morphogen gradients in neural tube development.Nature communications · 2022Article
- Avalanches during epithelial tissue growth; Uniform Growth and a drosophila eye disc model.PLoS computational biology · 2022Article
- EyeVolve, a modular PYTHON based model for simulating developmental eye type diversification.Frontiers in cell and developmental biology · 2022Article
- Review
- Improving the understanding of cytoneme-mediated morphogen gradients by in silico modeling.PLoS computational biology · 2021Article
- Interplay between sex determination cascade and major signaling pathways during Drosophila eye development: Perspectives for future research.Developmental biology · 2021Review
- Generation of extracellular morphogen gradients: the case for diffusion.Nature reviews. Genetics · 2021Review
- New regulators of Drosophila eye development identified from temporal transcriptome changes.Genetics · 2021Article
- Quantitative Relationships Between Growth, Differentiation, and Shape That ControlFrontiers in cell and developmental biology · 2021Article
- Human eye conditions: insights from the fly eye.Human genetics · 2019Review
- The proneural wave in theeLife · 2019Article
- Growth and size control during development.Open biology · 2017Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patterning and growth are linked during early development and have to be tightly controlled to result in a functional tissue or organ. During the development of the Drosophila eye, this linkage is particularly clear: the growth of the eye primordium mainly results from proliferating cells ahead of the morphogenetic furrow (MF), a moving signaling wave that sweeps across the tissue from the posterior to the anterior side, that induces proliferating cells anterior to it to differentiate and become cell cycle quiescent in its wake. Therefore, final eye disc size depends on the proliferation rate of undifferentiated cells and on the speed with which the MF sweeps across the eye disc. We developed a spatio-temporal model of the growing eye disc based on the regulatory interactions controlled by the signals Decapentaplegic (Dpp), Hedgehog (Hh) and the transcription factor Homothorax (Hth) and explored how the signaling patterns affect the movement of the MF and impact on eye disc growth. We used published and new quantitative data to parameterize the model. In particular, two crucial parameter values, the degradation rate of Hth and the diffusion coefficient of Hh, were measured. The model is able to reproduce the linear movement of the MF and the termination of growth of the primordium. We further show that the model can explain several mutant phenotypes, but fails to reproduce the previously observed scaling of the Dpp gradient in the anterior compartment.
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